参附注射液对下肢缺血再灌注诱发心肌损伤的保护作用  

Protection of Shenfu Injection on Lower Limb Ischemia Reperfusion-induced Myocardial Injury in Human

作　　者：瞿波[1] 于永群[1] 侯望平[1] 胡胜英[1] 陈旭华[1] 郑耀明[1] 

机构地区：[1]广东省江门市人民医院麻醉科,广东江门529000

出　　处：《中国实验方剂学杂志》2010年第7期201-203,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨参附注射液对下肢缺血再灌注诱发心肌损伤的保护作用。方法:40例拟行下肢骨科手术病人被随机分成2组,每组20例。所有病人均选择腰硬联合麻醉,对照组采用常规治疗,参附组在常规治疗的基础上在手术开始前加用参附注射液中静脉输注。分别从肘静脉采松止血带前(T1)、松止血带后30min(T2)、松止血带后120min(T3)等时间点血液,分离血清,检测肌钙蛋白I(cTnI),心肌酶谱。结果:与T1相比较,T2及T3时点的cTnI显著性增高(P<0.01),且在T3时点达到最高值。与对照组相比较,参附组T2及T3时点的cTnI增高的幅度显著降低(P<0.01)。结论:参附注射液能够降低心肌酶升高的幅度,对肢体缺血再灌注心肌损伤具有显著的保护作用。Objective：To discuss the protection of Shenfu injection on lower limb ischemia-reperfusion-induced myocardial injury in human. Method：40 patients with lower extremity orthopedic surgery were randomly divided into two groups,20 cases in each group. Combined spinal-epidural anesthesia was selected in all patients. Conventional treatment was used in control group. And on the base of control group,Shenfu injection was used in Shenfu group. Troponin I（cTnI） was detected before relaxing tourniquet（T1） ,30 min（T1） and 120 min（T3） after relaxing tourniquet. Result：Compared with that at T1,cTnI at T2 and T3 increased markedly（P 〈0. 01） ,and cTnI at T3 was the highest value. Compared with that in control group,the Increased range of cTnI at T2 and T3 in Shenfu group was decreased significantly（P 〈0. 01） . Conclusion：Shenfu injection can protect lower limb ischemia-reperfusion-induced myocardial injury in human.

关 键 词：参附注射液 心肌损伤 肌钙蛋白I 缺血再灌注 下肢 

分 类 号：R285.5[医药卫生—中药学]