北豆根总碱分散片的处方优化和稳定性实验  

Dispersible Tablets Formulation Optimization and Stability Test of Total Alkaloid of Menispermum Dauricum (TAMD)

作　　者：朱孝芹[1] 卜春红[1] 韩铁刚 刘翠哲[3] 李俊玫[1] 

机构地区：[1]承德医学院附属医院,河北承德067000 [2]盖州中西医结合医院,辽宁盖州115200 [3]承德医学院中药研究所,河北承德067000

出　　处：《中国实验方剂学杂志》2010年第8期11-14,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省卫生厅重大攻关项目(04006)

摘　　要：目的:确定北豆根总碱分散片的处方并考察其稳定性。方法:采用单因素考察和正交实验法,确定北豆根总碱分散片的处方;同时制备3批样品,进行质量考察和稳定性实验。结果:优化后的处方可以满足《中国药典》对分散片体外溶出结果的要求。结论:该分散片制剂制备工艺简单易行,适合工业化生产。Objective：To determine the dispersible tablets formulation and investigate its stability. Method： We determine the dispersible tablets formulation by one-factor investigation and orthogonal experimentmethod,at the same time,we prepare the batch sample,then go on quality investigationand stability test. Result： The formulation can satisfy the needs of dissolution rate of the dispersible tablets in vitro in ChP. Conclution：The preparation technology the dispersible tablets is simple and easy progress,and can be used in industrialized production.

关 键 词：北豆根总碱 分散片 稳定性 

分 类 号：R282.7[医药卫生—中药学] R284.2[医药卫生—中医学]