系统性红斑狼疮检测抗环瓜氨酸肽抗体分析  

Prevalence and clinical significance of anti-cyclic citrullinated peptide antibody in Systemic lupus erythematosus

作　　者：徐朝焰[1] 邓琼[1] 范忠晓[1] 林长艺[1] 林暖[1] 

机构地区：[1]福建医科大学附属三明第一医院风湿免疫科,福建三明365000

出　　处：《中国现代医学杂志》2010年第12期1810-1813,1817,共5页China Journal of Modern Medicine

基　　金：福建省三明市科技计划基金资助项目(No:2004-L-21)

摘　　要：目的探讨抗环瓜氨酸肽(CCP)抗体在系统性红斑狼疮(SLE)中的临床意义。方法分析SLE检测抗CCP抗体的情况,随访抗体阳性者,并与该抗体阴性的SLE进行临床资料对比。结果 149例SLE、168例类风湿性关节炎(RA)及106例非风湿病的抗CCP抗体阳性率分别为8.7%、69.6%和0。9例抗CCP抗体阳性SLE进行了复查,6例阳性,3例阴性。11例抗CCP抗体阳性SLE随访未发现关节侵蚀性病变。抗CCP抗体阳性SLE与40例阴性SLE在关节炎、关节侵蚀性病变等指标间的差异无统计学意义。结论抗CCP抗体仅在很小部分SLE中检出,对SLE与RA的鉴别诊断有重要价值,但其阳性不能作为完全排除SLE的指标,其出现在SLE中的临床意义尚不明确。【Objective】To investigate the prevalence and the clinical significance of anti-cyclic citrullinated peptide antibody（anti-CCP） in systemic lupus erythematosus （SLE）.【Methods】The prevalence of anti-CCP in patients with SLE was analyzed retrospectively. The patients with anti-CCP positive SLE were followed and their clinical features were compared with that of the patients with anti-CCP negative SLE.【Results】There were 149 patients included, of whom 13 patients （8.7%） were anti-CCP positive. The prevalence of anti-CCP was 69.6% and 0 in 168 patients with RA and 106 patients with non-rheumatic diseases, respectively. The follow-up of nine anti-CCP positive SLE showed that 6 were anti-CCP positive and 3 negative. No erosive arthritis was found during the follow-up of 11 anti-CCP positive SLE patients. There were no significant differences in clinical feature between anti-CCP positive and negative SLE. 【Conclusion】Anti-CCP can be detected only in a small part of patients with SLE so it is a useful serologic mark for the differentiation of RA and SLE, but its presence does not exclude a diagnosis of SLE absolutely. The clinical significance of anti-CCP antibody in SLE remains undefined.

关 键 词：抗环瓜氨酸肽抗体 系统性红斑狼疮 关节炎 

分 类 号：R446.62[医药卫生—诊断学] R593.241[医药卫生—临床医学]