罗红霉素缓释片的制备及体外释放度  

Preparation of roxithromycin sustained-release tablets and study on its drug release in vitro

作　　者：宁婷[1] 王秋[1] 李月[1] 冯婉玉[1] 

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001

出　　处：《中国医院药学杂志》2010年第13期1100-1103,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:以罗红霉素为模型药物,考察新型骨架材料KollidonSR在缓释片中的应用,制备罗红霉素缓释片并对其体外释放度进行考察。方法:以KollidonSR和HPMC为骨架材料,粉末直接压片法制备罗红霉素缓释片,采用正交设计优化处方,并考察其体外释放度影响因素。结果:所制备的罗红霉素缓释片释放曲线符合Higuchi方程,KollidonSR和HPMC的用量、填充剂用量、释放介质pH值、转篮转速对释药速度有较大影响,片剂硬度对释药速度无显著影响。结论:以KollidonSR和HPMC为骨架材料,可制备出具有理想释药行为的罗红霉素缓释片,制备工艺简便。OBJECTIVE Roxithromycin was selected as a model drug to study the effect of Kollidon SR on drug release. To prepare roxithromycin sustained release tablets and investigate the factors affecting the release profile in vitro. METHODS The optimal formulaton of roxithromycin sustained-release tablets was selected by orthogonal design using Kollidon SR and HPMC as matrix which was prepared by direct powder compression, and the factors affecting drug release was studied. RESULTS The release behavior of the tablets followed with Higuchi kinetic equation, and it was mainly eontrolled by the content of Kollidon SR and HPMC, character of filler, pH value of release medium, and rotation rate of basket. The influence of tablet hardness was not significant. CONCLUSION The sustained-release tablets have desirable release behavior. The preparation method is simple and applicable in production.

关 键 词：罗红霉素 缓释片 Kollidon SR 羟丙基甲基纤维素 释放度 

分 类 号：R944.9[医药卫生—药剂学]