抗肿瘤药物集中配置工作区间空气质量评价  

Evaluation of air quality at antineoplastic admixture center

作　　者：陈倩超[1] 刘韬[1] 黄红兵[1] 林沛亮[1] 毋福海[2] 郑志华 钟锦堂[1] 

机构地区：[1]华南肿瘤学国家重点实验室中山大学附属肿瘤医院药剂科,广东广州510060 [2]广东药学院公共卫生学院,广东广州510310 [3]广东省药学会,广东广州510080

出　　处：《中国医院药学杂志》2010年第13期1114-1117,共4页Chinese Journal of Hospital Pharmacy

基　　金：广东省社会发展领域科技计划项目(编号:73083);广东省药学会医院药学研究基金项目(编号:2009A004)

摘　　要：目的:通过监测抗肿瘤药物配置中心尘埃粒子数量、沉降菌数量及空气中药物(氟尿嘧啶)的浓度,考察配置中心内的空气质量。为制定更严格的防护措施及管理制度,保证输液质量及用药安全提供数据支持。方法:按GMP文件相关要求,对尘埃粒子及沉降菌进行检测;以氟尿嘧啶注射液作为样本,检测在工作不同时段及配置中心不同区域空气中氟尿嘧啶的浓度。结果:尘埃粒子及沉降菌的检测结果符合GMP要求;配置中心内所采集的空气样本检测出氟尿嘧啶。结论:不断改进配置中心的管理及防护技术,从多方面着手健全防护管理体系,加强环保和职业防护教育,避免药物对医护人员的伤害。OBJECTIVE To investigate the air quality in antineoplastic admixture center through monitoring the amount of dust particles, settling microbe and the concentration of fluorouracil （FU）. METHODS The quantity of dust particles and settling microbe were determined according to the relevant requirements of Good Manufacturing Practice （GMP）. The concentration of FU collected in various work periods and areas was determined. RESULTS The inspection results of the dust particles and settling bacteria meet the GMP requirement, and the trace amount of FU were detected in different gas samples. CONCLUSION The disposition of the dust particles and settling microbe met the GMP requirement in our center. And the results have provided the data for formulating the stricter protective measure and the control system, and ensuring the quality of the medication.

关 键 词：监测 抗肿瘤药物 空气检测 空气采样 

分 类 号：R954[医药卫生—药学]