不同浓度氢氧化钠消融胆道的研究  

Preliminary screening of sodium hydroxide for selective bile duct ablation and embolization

作　　者：杨爱军[1] 董家鸿[2] 

机构地区：[1]第三军医大学西南医院肝胆科,重庆400038 [2]解放军总医院肝胆外科

出　　处：《中华实验外科杂志》2010年第7期883-885,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 观察氢氧化钠溶液消融家兔胆道后肝脏病理及肝功能改变.方法 观察家兔右外叶胆道于5%至1%浓度氢氧化钠溶液消融后肝脏功能状态、组织病理改变和术后存活情况.结果 动物存活率100%（24/24）.各组间肝功能改变差异无统计学意义（P〉0.05）,但均与术前比较差异有统计学意义（P〈0.05）.5%氢氧化钠溶液组右外叶肝脏完全坏死（6/6）.2.5%氢氧化钠组右外叶肝脏几乎完全坏死（5/6）.1.5%氢氧化钠组右外叶以汇管区为中心的大片坏死（1/6）.1%氢氧化钠组右外叶以汇管区为中心的点片状坏死,肝叶边缘仅胆管坏死（0/6）.结论 1%为氢氧化钠溶液消融胆道的较理想浓度.Objective To observe the pathological changes after ablation with sodium hydroxide in intrahepatic bile ducts in rabbits. Methods Twenty-four rabbits were divided into group A （5% sodium hydroxide,n=6） , group B （2. 5% sodium hydroxide,n =6）, group C （1.5% sodium hydroxide,n =6） , group D （1% sodium hydroxide,n=6）. The hepatic histopathology and the survival rate of the rabbits were observed. Results No rabbits were dead after the ablation. In the group A, right external lobe liver was totally necrotized after ablation with 5% sodium hydroxide （6/6）. In the group B, right external lobe liver was barely completely necrotized after ablation with 2. 5% sodium hydroxide （5/6）. In the group C, liver tissues were massively necrotized （1/6）. In the group D, portal areas were necrotized（0/6）. The biliary tracts were necrotized at the edge of lobe and there was no obvious necrosis in hepatic tissues. Conclusion 1% is the proper concentration of sodium hydroxide for selective bile duct ablation.

关 键 词：肝内胆管结石 氢氧化钠 消融 病理改变 

分 类 号：R657.4[医药卫生—外科学]