刘寄奴黄酮类成分研究  

Flavonoids from Artemisia anomala

作　　者：温晶[1] 史海明[1] 刘艳芳[1] 昝珂[1] 周雨虹[1] 陈玉平[1] 屠鹏飞[1] 

机构地区：[1]北京大学药学院天然药物及仿生药物国家重点实验室,北京100191

出　　处：《中国中药杂志》2010年第14期1827-1830,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30973629)

摘　　要：目的:研究刘寄奴Artemisia anomala全草的化学成分。方法:柱色谱及高效液相色谱法分离其成分,波谱法鉴定其结构。结果:分离得到11个已知黄酮类化合物及2个黄酮木脂素类化合物,分别鉴定为山柰酚(1)、苜蓿素(2)、异泽兰黄素(3)、5,7,4′-三羟基-6,3′,5′-三甲氧基黄酮(4)、芒柄花素(5)、洋芹素(6)、柚皮素(7)、槲皮素(8)、毛蕊异黄酮(9)、芹菜素-7-O-葡萄糖苷(10)、山柰酚-3-O-芸香糖苷(11)、tricin 4′-O-(erythro-β-guaiacylglyceryl)ether(12)和tricin 4′-O-(threo-β-guai-acylglyceryl)ether(13)。结论:化合物12,13为首次从菊科中分离得到;化合物5,9为首次从蒿属中分离得到;化合物4,7,11为首次从该植物中分离得到。Objective： To study the constituents of Artemisia anomala.Method： The constituents were isolated by chromatographic methods,their structures were elucidated by spectroscopic evidences.Result： Eleven flavonoids and two flavanolignans were purified and their structures were identified.Conclusion： Compound 12 and 13 were isolated from the Compositae family for the first time.Compound 5 and 9 were firstly isolated from the genus Artemisia.Compounds 4,7,11 were isolated from A.anomala for the first time.

关 键 词：刘寄奴 菊科 蒿属 黄酮 化学成分 

分 类 号：R284[医药卫生—中药学]