中药及其提取纯化物对骨髓间充质干细胞诱导分化的研究进展  

Progressive studies on effects of traditional Chinese medicines on differentiation of human bone mesenchymal stem cells

作　　者：潘敏[1,2] 李玛琳[1,2] 

机构地区：[1]云南省天然药物药理重点实验室,云南昆明650500 [2]昆明医学院生物工程中心,云南昆明650500

出　　处：《中国中药杂志》2010年第14期1892-1895,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30860857);科技部重大新药创制专项(2008ZX09202005)

摘　　要：骨髓间充质干细胞具有多向分化的潜能,是目前干细胞领域的研究热点。许多研究者对中药及其提取纯化物对骨髓间充质干细胞分化的影响进行了探索。研究结果表明,部分中药及其提取纯化物能有效诱导骨髓间充质干细胞多向分化。例如三七皂苷能诱导骨髓间充质干细胞分化为神经细胞和心肌细胞,柚皮苷能诱导骨髓间充质干细胞分化为成骨细胞,右归饮的家兔含药血清诱导骨髓间充质干细胞分化为软骨细胞等。Bone marrow mesenchymal stem cells（BMSC） are a group of cells with the capability of self-renewal and potential of multilineage differentiation.It was reported that some traditional Chinese medicines and their extract have the potential to induce BMSC differentiate into multiple cells.For example,notoginse nosides can induce BMSC differentiate into neurons and myocytes,naringin can induce BMSC differentiate into osteoblast ,youguiyin-containing rabbit serum can induce BMSC differentiate into chondrocyte.This article reviews some progresses of this area in recent years.

关 键 词：中药 提取物 骨髓间充质干细胞 分化 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]