Box-Behnken设计-效应面法优化木犀草素-β-环糊精包合物的制备工艺研究  

Optimization of preparation for cyanidenon-β-cyclodextrin inclusion compound by Box-Behnken design and response surface method

作　　者：伍永富 吴品江[2] 魏萍[2] 吴大章[3] 

机构地区：[1]太极集团重庆涪陵制药厂有限公司,重庆408000 [2]成都中医药大学,四川成都611137 [3]太极集团重庆桐君阁药厂,重庆400066

出　　处：《中草药》2010年第7期1094-1099,共6页Chinese Traditional and Herbal Drugs

摘　　要：目的优化木犀草素-β-环糊精包合物的制备工艺。方法采用饱和水溶液法包合木犀草素,以包合率、收率和总评"归一值"为评价指标,采用Box-Behnken设计考察β-环糊精-木犀草素投料比例、包合时间、包合温度对制备工艺的影响,对结果进行多元线性和二项式拟合,效应面法选取最佳工艺条件进行预测分析。结果从相关系数上看,各项指标二项式拟合方程均优于多元线性回归方程,根据优化制备工艺制得木犀草素-β-环糊精包合物的平均包合率为75%,收率为66%。结论优化的木犀草素-β-环糊精包合物制备工艺稳定可行,包合率和收率同时都高,可用于生产。Objective To optimize the formulation of cyanidenon-β-cyclodextrin inclusion compound. Methods Cyanidenon-β-cyclodextrin inclusion compound was prepared by saturated water solution method. The effects of influence factors, such as ingredient proportion,inclusion time, inclusion temperature on inclusion rate, obtaining rate, and overall desirability were investigated by using Box-Behnken design and response surface method. The data were imitated using multi-linear equation and second-order polynomial equation. Results The latter was prior to the former considering from multiple correlation coefficients. Under the optimal conditions, inclusion rate and yield were 75% and 66%, respectively. Conclusion The optimized preparation technique for cyanidenon-β-cyclodextrin inclusion compound is stable, feasible, and has high inclusion rate. It can be used for the production of cyanidenon-β-cyclodextrin inclusion compound.

关 键 词：木犀草素 -β-环糊精包合物 BOX-BEHNKEN设计 效应面法 

分 类 号：R286.02[医药卫生—中药学]