煨制川木香对家兔离体肠肌解痉作用的研究  

Effect of Baked Radix Vladimiriae on the Spasm of in Vitro Intestinal Muscle in Rabbit

作　　者：瞿燕[1] 傅超美[1] 胡慧玲[1] 章津铭[1] 许丽佳[1] 

机构地区：[1]成都中医药大学药学院,成都市610075

出　　处：《中国药房》2010年第27期2503-2505,共3页China Pharmacy

基　　金：四川省科技厅基金资助项目(07JY029-093)

摘　　要：目的:研究煨制川木香对家兔离体肠肌的解痉作用。方法:用Magnus离体肠肌累积剂量法观察煨制川木香石油醚部位对家兔离体肠管作用的量效关系,及其对乙酰胆碱、磷酸组胺及氯化钡(Bacl2)所致家兔肠管痉挛的影响。结果:煨制川木香石油醚部位对家兔离体肠管收缩的抑制作用呈一定的量效关系,表现出拮抗乙酰胆碱、磷酸组胺及Bacl2的作用。结论:煨制川木香石油醚部位对正常离体肠肌具有抑制作用,且随剂量增加而作用增强。其机制可能与乙酰胆碱、组胺竞争,阻断M、H1受体,并直接抑制肠肌兴奋性有关。OBJECTIVE：To explore the spasmolytic effect of baked Radix Vladimiriae on in vitro intestinal muscle in rabbits. METHODS：Magnus in vitro intestinal muscle accumulative dose method was adopted to observe the dose-effect relationship of petroleum ether parts of baked Radix Vladimiriae with in vitro intestinal muscle of rabbits and its impact on the spasm of rabbit intestinal muscle induced by acetylcholine, histamine phosphate and Bacl2. RESULTS：There was a certain dose-effect relationship between petroleum ether parts of baked Radix Vladimiriae and spasmolytic mechanism of rabbit in vitro intestine. It showed the effect of acetylcholine, histamine phosphate and Bacl2. CONCLUSION：The inhibition effect of petroleum ether parts of baked Radix Vladimiriae on normal in vitro intestinal muscle increase as long as dose increase. The inhibition mechanism may be associated with acetylcholine competing with histamine to block M receptor and H1 receptor as well as to inhibit excitability of intestinal muscle.

关 键 词：川木香 煨制 离体肠肌 解痉 

分 类 号：R969.1[医药卫生—药理学] R971.1[医药卫生—药学]