正交试验优选氧化苦参碱毫微粒的制备工艺  

Optimization of the Preparation Technology of Oxymatrine Nanoparticle by Orthogonal Experiment

作　　者：白晓朝[1] 

机构地区：[1]宁夏师范学院化学与化学工程学院,固原市756000

出　　处：《中国药房》2010年第27期2517-2519,共3页China Pharmacy

摘　　要：目的:优选氧化苦参碱毫微粒的制备工艺。方法:采用正交试验法,以包封率和载药量为评价指标,以氧化苦参碱的用量、聚氰基丙烯酸正丁酯的用量、介质的pH值、混合时间为因素优选制备工艺。结果:最佳优化条件为160mg的氧化苦参碱及80mg的聚氰基丙烯酸正丁酯在pH2.0的条件下混合3h,载药量为(16.90±0.25)%,包封率为(72.75±0.19)%。结论:优选处方和制备工艺稳定可行,可为开发氧化苦参碱的新剂型提供参考。OBJECTIVE：To optimize the preparation technology of oxymatrine nanoparticle. METHODS：The extraction technology of oxymatrine nanoparticle was optimized by orthogonal experiment with encapsulation coefficency and drug-loading rate as index and with the amount of oxymatrine and polybutylcyanoacrylate, pH value of medium and mixing time as factors. RESULTS：The optimal preparation condition oxymatrine 160 mg mixed with polybutylcyanoacrylate 80 mg at the pH value of 2.0 for 3 hours with drug-loading rate of （16.90±0.25）% and encapsulation coefficency of （72.75±0.19）%. CONCLUSION：The optimized prescription and preparation technology of oxymatrine are stable and practicable, which provide reference for the development of new dosage form of oxymatrine.

关 键 词：氧化苦参碱 毫微粒 制备工艺 质量评价 

分 类 号：R283[医药卫生—中药学] R97[医药卫生—中医学]