复方中药组方对阳虚证小鼠神经内分泌免疫功能影响的实验研究  

Experimental Study on Effects of Chinese Medical Compound Prescription on Neuroendocrine Immune Functions in Mice with Yang Deficiency Syndrome

作　　者：卢建平[1] 张媛 过怿赟[1] 张新路[1] 许业松[1] 程宜福[1] 许钒[3] 

机构地区：[1]皖南医学院弋矶山医院,安徽皖南241001 [2]芜湖市中医医院,安徽芜湖241001 [3]安徽中医学院,合肥230000

出　　处：《中国中医基础医学杂志》2010年第6期477-479,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：皖南医学院中青年科研基金资助项目(WK200820F)

摘　　要：目的:探讨复方中药组方对阳虚证小鼠神经内分泌免疫(NEI)功能的影响。方法:采用氢化可的松小鼠阳虚证模型,随机分为4组,分别与生理盐水、复方中药及其拆方,另设空白对照组,测定体重和体温变化,测定ATCH、CORT、TSH、T3、T4的水平和胸腺指数、脾脏指数的变化。结果:模型具有明显的NEI功能紊乱,中药干预组不同程度地提高了ATCH、CORT、TSH、T3、T4的水平和胸腺指数,降低了脾脏指数。结论:复方中药及其拆方能不同程度地调节NEI功能。Objective To study the effects of WenYan-HuaTan-ZiYin Decoction and its Decomposed formulas on Neuro-endocrino-immune Functions in Mice Model of Yang Deficiency. Methods The mice were randomly divided into the normal control Group,Yang Deficiency model Group,Yang Deficiency and WenYan-HuaTan Decoction-Group,Yang Deficiency and ZiYin Decoction-Group,Yang Deficiency and WenYan-HuaTan-ZiYin Decoction-Group. Yang Deficiency models of mice were established by hydrocortisone. Research the body quality and temperature during the experiment. By the end of the experiment,the spleen and thymus were removed rapidly and weighted when the mice were killed,the spleen index and the thymus index were calculated,and the contents of Adrenocoticotrophic Hormone （ACTH）,Cortisol （CORT）,Thyroid Stimulating Hormone （TSH）,Triiodothyronine （T3） and Thyroxine （T4 ） in the serum were measured by Radio-immunity method. Results The body quality and temperature,the content of ACTH,CORT,TSH,T3,T4 and the thymus index of Yang Deficiency animals treated by WenYan-HuaTan-ZiYin Decoction and its Decomposed formulas increased but spleen index decreased. Conclusion WenYan-HuaTan-ZiYin Decoction and its Decomposed formulas can ameliorate the function of the Neuro-endocrino-immune net.

关 键 词：阳虚证 神经内分泌免疫功能 滋阴填精 温阳化痰复方中药 拆方 

分 类 号：R285.5[医药卫生—中药学]