复方醋酸地塞米松乳膏含量测定异常的临床研究  

Abnormality in assay of compound dexamethasone acetate cream

作　　者：彭辽宇 覃志高 李如栋 

机构地区：[1]武警广西总队医院药局,南宁530003 [2]南宁食品药品检验所,530001

出　　处：《武警医学》2010年第7期592-594,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的对复方醋酸地塞米松乳膏含量测定的异常情况进行分析。方法改变复方醋酸地塞米松乳膏含量测定中的流动相比例,更换不同厂家的色谱柱,用二极管阵列检测器的紫外扫描图谱进行定性。结果样品在更换合适的色谱柱及调节适宜的流动相比例后,可以消除异常情况。结论当用高效液相色谱法测定药品的含量出现异常时,应考虑更换不同的色谱柱、调节流动相的比例及更换检验人员进行试验,从而查找出并解决含量测定异常的原因。Objective To analyze the abnormality in assay of compound dexamethasone acetate cream. Method During assay of compound dexamethasone acetate cream, the proportion of the mobile phase was changed, the columns of different manufacturers were replaced, and a UV diode array detector was used to scan a qualitative map. Results Samples in the appropriate column, with a changed proportion of the mobile phase, were free of anomalies. Conclusion When abnormal contents of drugs appear in HPLC, it is advisable to use a different column, adjust the proportion of the mobile phase and replace inspectors in order to find the cause of abnormalities.

关 键 词：醋酸地塞米松 含量测定 分析 

分 类 号：R927.1[医药卫生—药学]