骨髓增生异常综合征合并骨髓纤维化的临床和病理特点分析  

The clinical features and results of cell/tissue morphology of myelodysplastic syndrome associated with myelofibrosis

作　　者：张剑[1] 董家蔷[1] 聂泽强[1] 王京华[1] 李晓云[1] 方敏[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院血液科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2010年第3期271-273,276,共4页Journal of Harbin Medical University

摘　　要：目的分析骨髓增生异常综合征合并骨髓纤维化(MDS-MF)的临床表现和病理特点,进一步提高对MDS-MF的认识。方法患者初诊时做血常规、骨髓涂片、骨髓活检并采用网状纤维染色(Gomori),根据阳性结果判定纤维化的程度。结果 MDS合并MF组分别在年龄、血红蛋白(HGB)、血小板(PLT)数值上与MDS不合并MF组存在显著性差异(P<0.05),且临床表现明显。Gomori染色阳性以"+++"为主。结论 MDS-MF是一种性质独立的临床病理类型,应与其他MDS亚型区分。Objective To further study the clinical features and results of cell/tissue morphology of myelodysplastic syndrome（MDS） associated with myelofibrosis（MDS-MF）.Methods New patients blood roution,bone marrow,bone marrow biopsy were used in new patients and used Gomori method to judge-degnee of fibrosis.Results There was significant difference between the age 、HGB、PLT of MDS-MF and MDS not associated with Myelofibrosis（P〈0.05）,MDS-MF had obvious clinical manifestation.Most of MDS-MF patients Gomori＇s stain showed＂＋＋＋ ＂positive.Conclusion MDS-MF may be a distinct clinical pathological entity which needs to be distinguished from other MDS subtype as well as from idiopathic myelofibrosis.

关 键 词：骨髓增生异常综合征 骨髓纤维化 骨髓活检 

分 类 号：R551.3[医药卫生—血液循环系统疾病]