细胞因子及生化指标在婴儿肝炎综合征诊断中的应用  

Application of serum cytokines and biochemical constituents to the diagnosis of infantile hepatitis syndrome

作　　者：佟菲[1] 王丹[1] 于峰[1] 代力[1] 吴悦[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院检验科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2010年第3期274-276,共3页Journal of Harbin Medical University

摘　　要：目的分析婴儿肝炎综合征(infantile hepatitis syndrome,IHS)患儿血清生化指标及细胞因子的变化情况。方法对36例IHS患儿(分为胆汁淤积型和肝炎型)及25例对照组血液标本的TBIL、DBIL、ALT、γ-GT、TBA、IL-6和TNF-α进行检测。结果与对照组相比,胆汁淤积组和肝炎组的所有指标都明显增高;肝炎组患儿与对照组相比,除血清中TBIL含量两者没有明显差异外,其它指标都明显增高;胆汁淤积组与肝炎组相比,除ALT和TBA在这两组中没有明显差异,其它指标都明显增高。结论 IHS患儿中胆汁淤积型病情更加严重。Objective To investigate the serum biochemical constituents and cytokines in infantile hepatitis syndrome（IHS）.Methods From 36 IHS subjects and 25 controls,serum biochemical constituents,including TBIL,DBIL,ALT,γ-GT,TBA,IL-6 and TNF-α in serum,were assayed.The subjects with IHS were divided into cholestasis group and hepatitis group.Results In the cholestasis group and hepatitis group,serum TBIL,DBIL,ALT,γ-GT,TBA,IL-6 and TNF-α levels were higher than those in the control;In the hepatitis group,serum DBIL,ALT,γ-GT,TBA,IL-6 and TNF-α levels were higher than those in the control.Serum TBIL,DBIL,γ-GT,IL-6 and TNF-α levels in the cholestasis group were higher than those in the hepatitis group.Conclusion Cholestasis has more serious condition in IHS patients.

关 键 词：婴儿肝炎综合征 生化指标 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R72[医药卫生—儿科] R575.1[医药卫生—临床医学]