姜黄素衍生物FM0807体内外抗肿瘤作用研究  

Antitumor Effect of Curcumin Derivative FM0807 in vitro and in vivo

作　　者：叶丽香[1] 张志强[2] 刘洋[3] 李鹏[4] 许建华[1,2] 

机构地区：[1]福建医科大学药学院,福州350004 [2]福建医科大学新药研究所,福州350004 [3]福建医科大学药物化学系,福州350004 [4]福建医科大学天然药物化学系,福州350004

出　　处：《福建医科大学学报》2010年第3期161-164,共4页Journal of Fujian Medical University

基　　金：国家自然科学基金(30873101);福建省科技重点项目(2009Y0025);2008年福建省产业技术开发项目(2008B91)

摘　　要：目的研究姜黄素衍生物FM0807的体内外抗肿瘤作用。方法应用四甲基偶氮唑蓝(MTT)法检测FM0807对多种肿瘤细胞生长的抑制作用;建立H22小鼠移植肿瘤模型进行体内实验,观察尾静脉、腹腔及口服给予FM0807后体内抗肿瘤活性。结果体外抗肿瘤研究表明,FM0807对K562,HL260,MGC-803,HepG2,Sw480等多种人肿瘤细胞均有生长抑制作用,IC50分别为5.21,6.25,7.37,24.72,9.72μg/mL;体内抗肿瘤研究表明,尾静脉、腹腔及口服给予FM0807后对小鼠H22肿瘤生长均有明显抑制作用,抑制率分别达到69.0%,66.3%,52.5%。结论 FM0807体内外均有较强抗肿瘤作用。Objective To evaluate the antitumor effect of FM0807 in vitro and in vivo.Methods The MTT assay was used to examine the growth arrest of a variety of tumor cells by FM0807.The H22 mouse tumor xenograft models were established and antitumor effect of FM0807 given by tail vein injection,intraperitoneal injection and oral administration respectively was measured.Results FM0807 remarkably inhibited the proliferation of many kinds of tumor cells.The IC50 values to K562,HL60,MGC-803,HepG2 and SW480 were 5.21,6.25,7.37,24.72 and 9.72 μg/mL respectively.FM0807 showed significant inhibitory effect on H22,the inhibitory rates of FM0807 given by tail vein injection,intraperitoneal injection and oral administration were 69.0%,66.3%,52.5%,respectively.Conclusion FM0807 was able to inhibit potently the growth of the tumor cells in vitro and in vivo.

关 键 词：姜黄素 抗肿瘤药 肿瘤移植 疾病模型 动物 

分 类 号：R285.5[医药卫生—中药学]