姜黄素微球的制备及缓释性能研究  

Preparation of Curcumin-Loaded Microspheres and Their Sustained Release Performance

作　　者：林媚[1] 林晨[1] 刘洋[1] 

机构地区：[1]福建医科大学药学院药物化学系,福州350004

出　　处：《福建医科大学学报》2010年第3期178-181,共4页Journal of Fujian Medical University

基　　金：福建省科技厅青年人才项目(2008F3049)

摘　　要：目的以聚己内酯为载体制备姜黄素微球以期延长姜黄素的释放时间,研究聚合物分子量对缓释性能的影响,探讨药物释放动力学行为。方法采用水包油(O/W)乳化和溶剂挥发法相结合制备载药微球,采用偏光显微镜、扫描电镜表征微球的形态和粒径,UV-VIS分光光谱仪在426 nm处测定微球的载药率、包封率及药物释放行为。结果制备得到粒径<10μm的微球,聚己内酯分子量越大,姜黄素释放时间越长,且药物释放满足Fickian扩散方程。结论聚己内酯能有效延长姜黄素的释放时间,可以通过调节聚己内酯的分子量来调节药物释放行为。Objective To prepare Curcumin-loaded microspheres with poly-ε-caprolactone in order to prolong the release time of drug and to study the effect of polymer molecular weight on the sustained release performance and the drug release kinetics.Methods Drug-loaded microspheres were fabricated by oil-in-water（O/W） emulsion and solvent evaporation technique.The shape and size of the produced microspheres were measured with Polarized microscope and scanning electron microscope.Drug encapsulation and loading efficiency as well as drug release behavior of the microspheres were determined by UV-VIS spectrophotometer.Results Microspheres less than 10 μm in size were prepared.It was found that the larger polymer molecular weight,the longer sustained release time.In addition,the drug release behavior of microspheres fitted well with the Fickian diffusion model.Conclusion Poly-ε-caprolactone can effectively prolong curcumin release time,and the release behavior can be tuned by molecular weight of polymer.

关 键 词：姜黄素 工艺学 制药 聚合物 微球体 内酯类 

分 类 号：R283[医药卫生—中药学]