天泰1号对Aβ_(25-35)联合D-半乳糖诱导老年性痴呆模型的干预作用研究  

The Intervention of tiantai 1 on the Model of Alzheimer's diseas Induced by Aβ_(25-35) and D-galactose

作　　者：刘洋[1] 吴正治[2] 

机构地区：[1]南方医科大学 [2]南方医科大学附属深圳医院,广东深圳518035

出　　处：《中医药导报》2010年第7期92-95,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:观察Aβ25-35联合D-半乳糖诱导大鼠阿尔茨海默病(AD)动物模型认知功能变化及天泰1号的干预作用。方法:应用脑立体定位仪双侧海马内一次性注射Aβ25-35,联合长期颈部皮下注射D-半乳糖制作大鼠AD动物模型,注射24h后灌胃给药,连续30d,以morris水迷宫进行认知行为学检测。结果:与正常对照组、假手术组比较,AD模型组大鼠水迷宫行为学检测潜伏期明显延长,中药组给药后与给药前相比较,潜伏期明显缩短。结论:本方法建立的AD模型大鼠学习记忆功能显著障碍,天泰1号对Aβ25-35诱导的阿尔茨海默病大鼠模型的学习记忆能力具有显著的改善作用。Objective：Observation the change in cognitive function and the intervention of tiantai 1 by injection of Aβ25-35 and D-galactose into the bilateral hippocampal of rats. Methods： Aβ25-35 was injected into the bilateral hippocampus one-time and D-galactose was injected into the subcutaneous of neck to establish AD model by applications of the brain three-dimensional positioning instruments,tiantai 1 was given after 24 hours,lasted for 30days,the cognitive behavior was tested by morris water. Results： compared with normal control group and Sham-operated group the leaming and memory ability was prolong in model rats,compared with no chinese herbal medicine group the leaming and memory ability was significantly shorter in chinese herbal medicine group. Conclusion： the learning and memory function was apparent obstacled by this method to establishment the rat model,Aβ25-35-induced rat model of Alzheimer＇s diseas,the learning and memory can be improved by tiantai 1.

关 键 词：AΒ25-35 D-半乳糖 天泰1号 MORRIS水迷宫 动物模型 阿尔茨海默病(老年性痴呆) 

分 类 号：R285.5[医药卫生—中药学]