基于体素的形态测量学在震颤麻痹型多系统萎缩中的应用  

Voxel-based morphometry in the Parldnson variant of multiple system atrophy

作　　者：赵彦萍[1] 王含[2] 李琢[1] 冯逢[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,100730 [2]中国医学科学院北京协和医学院北京协和医院神经内科

出　　处：《中华放射学杂志》2010年第7期682-686,共5页Chinese Journal of Radiology

基　　金：国家自然科学基金资助项目（30670608）

摘　　要：目的 评价震颤麻痹型多系统萎缩（MSA-P型）患者全脑灰、白质体积减少区域及分布特征。方法选取13例临床拟诊为MSA-P型可能性大的患者及14名年龄匹配的正常对照者行全脑三维快速扰相梯度回波（3D fast spoiled gradient echo，3D．FSPGR）序列扫描，采用基于体素的形态测量学（voxel-based morphometry，VBM）分析方法的统计参数图软件（statistical parametric mapping，SPM）8，对MSA—P型患者及正常对照者的灰、白质体素进行分析。结果与正常对照者相比，MSA-P患者的脑灰、白质体积均减少；脑灰质减少区多数区域呈双侧对称分布：包括双侧辅助运动区、背侧后扣带皮层、额叶内侧回、颞上回、小脑半球皮层等；少数区域仅累及单侧，如右侧初级运动皮层、体感联合皮层及左侧下前扣带皮层等。脑白质区主要累及双侧额上回、楔前叶、额叶下，左侧颞上回、扣带回及右侧额眶回、颞叶下等。结论VBM方法具有自动、全面的特点，能客观地反映MSA-P患者组全脑结构的差异。Objective To assess patterns of the gray and white matter atrophy in patients with multiple system atrophy-P （MSA-P） variant of whole brain compared with normal controls. Methods Three dimensional fast spoiled gradient echo（3D-FSPGR） T1WI of whole brain were obtained from 13 patients with probable MSA-P and 14 age-matched normal controls. The volume of gray matter （GM） and white matter （WM） of MSA-P patients and normal controls was analyzed with voxel-based morphometry （ VBM ） using statistical parametric mapping （SPM） 8. Results Compared with the controls, the MSA-P patients showed decreased gray matter and white matter in broad areas. Gray matter loss mainly symmetrically distributed in bilateral supplementary motor area （SMA）, dorsal posterior cingulate cortex （DPCC）, medial frontal gyrus, superior temporal gyrus, cerebellum cortex, etc. Unilateral involvement of cortices mainly located in right primary motor cortex, somatosensory association cortex （SAC）, and left ventral anterior eingulate cortex （VACC）. There was white matter loss in bilateral superior frontal gyrus, bilateral precuneus, bilateral subgyrus of frontal lobe, left superior temporal gyrus, left cingulate gyrus, right orhitofrontal area, right subgyrus of temporal lobe, etc. Conclusion VBM method is an automatic and comprehensive volumetry method and can objectively detect the difference of the whole brain structure in patients with probable MSA-P comparing with normal controls.

关 键 词：多系统萎缩 磁共振成像 人体测量术 

分 类 号：R445.2[医药卫生—影像医学与核医学]