微流控芯片在细胞微环境研究中的应用  

Application of Microfluidic Chips in Cellular Microenvironment

作　　者：卢斯媛[1] 蔡绍皙[1] 蒋稼欢[1] 

机构地区：[1]重庆大学生物工程学院,重庆400044

出　　处：《生物医学工程学杂志》2010年第3期675-679,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10872224)

摘　　要：微流控芯片是一种新型的技术平台,它通过在不同的芯片材料上构造出微米级的通道结构,结合微流体控制技术,能够相对精确地模拟细胞在生理或病理状态下的各种微环境,在细胞研究中有着独特的优势。本文综述了微流控芯片的设计和制作,及其在细胞培养与细胞研究中的应用,着重介绍了微流控芯片在控制细胞微环境上的优越性。Microfluidic chip is a novel technology platform,in which microchannels are fabricated in different materials. The ability to precisely control the microflows makes it possible to mimic the microenvironment of cells in physiological or pathological states,which provides many distinct advantages for cell research. In this paper are reviewed the design and fabrication of microfluidic chip,the application of microfluidic chip in cell culture and cell researches; the enormous advantages of microfluidic chips in precise experimental control of the cellular microenvironment are introduced.

关 键 词：微流控芯片 微环境 血管发生 肿瘤转移 神经生长 

分 类 号：TN492[电子电信—微电子学与固体电子学]