新型聚氨酯心脏瓣膜的组织相容性试验  

Histocompatibility of a novel polyurethane material for construction of prosthetic heart valve

作　　者：郭利明[1] 李子林 段维勋[3] 徐学增[3] 刘金成[3] 

机构地区：[1]成都医学院第一附属医院胸心外科,四川成都610500 [2]解放军第四五二医院胸心外科,四川成都610061 [3]第四军医大学西京医院心血管外科,陕西西安710038

出　　处：《心脏杂志》2010年第4期592-594,共3页Chinese Heart Journal

基　　金：陕西省攻关计划资助[2006k13-G1(12)]

摘　　要：目的:评价由聚已二酸亚己酯(PDMS)与二甲基硅醚聚合物(PHMO)所构建的新型聚氨酯弹性体作为人工心脏瓣膜材料的可行性。方法:用此材料做致敏试验、全身急性毒性试验和致癌实验,评价其组织相容性。结果:此材料组织相容性良好,致敏试验提示新型聚氨酯材料较对照组有较明显的防止过敏的性能(P<0.05,P<0.01);全身急性毒性试验显示出明显的低毒性(P<0.01);致癌实验提示未见肿瘤样变化。结论:此种新型聚氨酯材料符合人工心脏瓣膜材料组织相容性的要求。AIM： To evaluate the histocompatibility of a novel polyurethane material used for the construction of prosthetic heart valves. METHODS： Evaluations including hemolysis, stimulation and systemic acute toxicity tests were performed. Polyurethane extracts were injected subcutaneously （SC） in rabbits and intravenously （IV） in mice. Histological and animal responses after 72 h were studied. RESULTS： This material has displayed good histocompatibility. No toxicity was observed. Primary skin irritation test showed no erythema, eschar or edema. CONCLUSION： This novel polyurethane material meets the requirements for material characteristics used for the construction of prosthetic heart valves.

关 键 词：聚氨酯 组织相容性 人工心脏瓣膜 

分 类 号：R318.08[医药卫生—生物医学工程]