自然分娩慢性HBV感染妊娠患者母婴传播相关因素分析  

Risk factors of mother to child transmission in CHB pregnant women with vaginal delivery

作　　者：诸思赟[1] 蒋音[1] 张丹丹[1] 王磊[1] 陈良[1] 

机构地区：[1]上海市(复旦大学附属)公共卫生临床中心,201508

出　　处：《肝脏》2010年第3期164-166,共3页Chinese Hepatology

摘　　要：目的探讨自然分娩慢性HBV感染妊娠患者血清乙型肝炎标志物及HBVDNA载量与HBV母婴传播的风险。方法选择58例自然分娩的慢性HBV感染妊娠患者,检测其分娩前肝功能、血清乙型肝炎标志物及HBVDNA载量,并同时检测其新生儿外周血及脐血血清乙型肝炎标志物及HBVDNA载量。结果妊娠患者HBeAg阳性率与婴儿HBeAg阳性率相关;妊娠患者HBVDNA载量与婴儿HBeAg阳性率相关;妊娠患者分娩时肝功能正常与否与婴儿HBeAg阳性率无关。结论妊娠患者分娩前HBeAg阳性和HBVDNA高载量是HBV母婴传播的危险因素,而其分娩前肝功能正常与否可能与母婴传播风险无关。Objective To explore the risk of mother to child transmission in vaginal delivery women with chronic HBV infection by HBV markers and HBV DNA loading.Methods Liver function,serum HBV markers and HBV DNA load of 58 pregnant women with vaginal delivery were tested before giving birth,and the serum HBV markers and HBV DNA load of their infant were tested after birth.Results The HBeAg-positive rate of infants was associated with the mothers＇ HBeAg positive rate.The HBeAg-positive rate of infants was associated with the mothers＇ HBeAg-positive rate;The mothers＇ liver function of pregnant during childbirth has no correlation with HBeAg-positive rate of infants.Conclusion High viral load with HBeAg-positive before delivery is one of the factors of vertical/maternal transmission of HBV,while the liver function of pregnant before childbirth is not.

关 键 词：母婴传播 乙型肝炎病毒 乙型肝炎E抗原 乙型肝炎病毒DNA 

分 类 号：R512.62[医药卫生—内科学]