采用基于纤维束示踪的空间统计分析方法观察先天性耳聋患者的脑白质改变  

Investigation of the white matter with tract-based spatial statistics in congenitally deaf patients

作　　者：刘兆会[1] 李猛[2] 鲜军舫[1] 何晖光[2] 王振常[1] 李勇[1] 李建红[1] 王晓翠[3] 刘莎[3] 

机构地区：[1]首都医科大学附属北京同仁医院放射科,北京100730 [2]中国科学院自动化研究所复杂系统与智能科学重点实验室,北京100190 [3]首都医科大学附属北京同仁医院耳鼻咽喉-头颈外科,北京100730

出　　处：《中国医学影像技术》2010年第7期1226-1229,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(60875079);北京市科技新星资助项目(2004-B-31;2007A094);北京市自然科学基金(7082026;7062019);北京市教委科技发展计划(KM200710025020);高校博士点专项基金(20060025002);2009年人力资源和社会保障部留学人员科技活动择优资助经费启动类项目

摘　　要：目的应用基于纤维束示踪的空间统计分析(TBSS)方法 ,观察先天性感音神经性耳聋患者听觉中枢及相关中枢的脑白质改变。方法对15例先天性耳聋患者和28名正常志愿者的听觉中枢及相关中枢进行扩散张量成像(DTI)及三维快速扰相梯度回波数据采集。应用TBSS对先天性耳聋患者和正常志愿者的DTI数据进行分析,获取部分各向异性(FA)值具有显著性差异的脑区。结果与正常志愿者相比,先天性耳聋患者的双侧额下回、颞横回、颞上回、颞中回中后部内侧的脑白质以及双侧内囊前肢、外囊、视辐射FA值显著下降(P<0.05),左侧颞中回中后部内侧脑白质及视辐射FA值下降的范围大于右侧。结论先天性耳聋患者听觉中枢及相关中枢脑白质FA值显著下降,提示出入听觉中枢及相关中枢的脑白质纤维髓鞘形成不良和(或)白质纤维数量减少。Objective To evaluate changes of white matter of auditory brain and associated brain regions with tract-based spatial statistics （TBSS） of diffusion tensor imaging （DTI） data in congenitally deaf patients. Methods DTI data of auditory brain and associated brain regions and three dimensional fast spoiled gradient echo sequence of the whole brain were completed in 15 patients with congenital deaf patients and 28 healthy volunteers. Fractional anisotropy （FA） values of the white matter in congenital deaf patients were compared with those in volunteers with TBSS of DTI data. Results Compared with volunteers,FA values significantly decreased in the white matter of bilateral inferior frontal gyri,superior temporal gyrus,posterior medial portion of middle temporal gyrus,bilateral anterior limbs of internal capsule,external capsule,optic radiation in congenitally deaf patients （P〈0.05）. The extent of decrease of FA value in the white matter of posterior medial portion of left middle temporal gyrus and left optic radiation was larger than that in the right in congenitally deaf patients. Conclusion Significant decrease of FA value in the white matter of auditory brain and associated brain regions is demonstrated in congenitally deaf patients,suggesting hypomyelination and/or fewer fibers of these brain regions.

关 键 词：聋 脑 部分各向异性 扩散磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R764.43[医药卫生—诊断学]