^(18)F-FDG PET/CT评价伽马刀治疗肿瘤疗效  

^(18)F-FDG PET/CT in assessment of therapeutic efficiency of γ-knife for malignant tumors

作　　者：川玲[1] 赵文锐[1] 梁英魁[1] 方庭正[1] 王升[1] 王新强[1] 高春华[1] 王春方[1] 王伟[1] 

机构地区：[1]中国人民解放军海军总医院核医学科,北京100048

出　　处：《中国介入影像与治疗学》2010年第4期455-458,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：首都发展基金(20073031)

摘　　要：目的探讨18F-FDG PET/CT在评价伽马刀治疗肿瘤疗效中的价值。方法对39例肿瘤术后复发患者,在伽马刀治疗前和治疗后3个月,根据CT显像的病灶大小、PET显像的平均标准摄取值(SUVmean)变化以及SUV变化率(△SUV)分别进行近期疗效判定。结果治疗前PET/CT全身检查后检出病灶并行伽马刀定位病灶65个,平均直径(3.32±3.57)cm;平均SUVmean5.92±2.62。伽马刀治疗3个月后复查,PET/CT检出病灶50个,平均直径(2.54±2.76)cm;平均SUVmean3.82±3.40。伽马刀治疗后病灶最大直径普遍较前缩小(P<0.05),伽马刀治疗后SUVmean显著降低(P<0.001)。伽马刀治疗后CT显示的总有效率为38.46%(25/65),PET SUVmean显示总有效率为55.38%(36/65),二者之间差异有统计学意义(χ2=6.24,P<0.05)。△SUV的总有效率为49.23%(32/65)。结论 18F-FDG PET/CT可以从病灶的大小和代谢两方面评价伽马刀治疗肿瘤的疗效。Objective To explore clinical application of 18F-FDG PET/CT for assessing the efficiency of γ-knife in treating patients with malignant tumors before and after therapy.Methods Thirty-nine patients were enrolled in the study.All the patients were examined using 18F-FDG PET/CT before and 3 months after γ-knife therapy.Mean standardized uptake value（SUVmean）value,tumor size and percentage of SUVs changes（△SUV）were measured.Results The changes were significant in size of lesions（[3.32±3.57]cm vs [2.54±2.76]cm）and in SUVmean（5.92±2.62 vs 3.82±3.40）before and after therapy（P0.05）.The total efficiency rate of CT evaluation was 38.46%（25/65）,and SUVmean of PET was 55.38%（36/65）after γ-knife treatment.There was significance difference between the size of CT and the SUVmean of PET imaging（χ2=6.24,P0.05）.The total efficiency rate of △SUV was 49.23%（32/65）.Conclusion 18F-FDG PET/CT has high clinical value in the diagnosis and evaluation of the efficiency of γ-knife treatment for malignant tumors.

关 键 词：体层摄影术 正电子发射型 肿瘤 治疗 伽马刀 氟脱氧葡萄糖F18 

分 类 号：R817[医药卫生—影像医学与核医学]