表皮内T细胞与药疹  

Epidermal T lymphocytes and drug eruption

作　　者：金德蕙[1] 宋亚丽[1] 张莉[1] 

机构地区：[1]山东大学附属省立医院皮肤科,济南250021

出　　处：《国际皮肤性病学杂志》2010年第4期207-209,共3页International Journal of Dermatology and Venereology

摘　　要：药疹是药物通过注射、口服、吸入等途径进入人体后引起的皮肤黏膜反应，其临床表现多种多样，发生机制非常复杂。研究提示，细胞毒性T细胞参与多种类型药疹的发病。药疹的组织病理改变主要表现为表皮损伤，多项研究发现，表皮内T细胞在药疹的表皮损伤中发挥重要作用，概述表皮内T细胞对其表型、功能、活化调控、效应途径及其在药疹中的作用。Drug eruption, a mucoeutaneous reaction following the entry of drugs into body through injection, oral administration or inhalation, has various clinical manifestations with complex pathogenesis. Recent studies suggest that cytotoxic T lymphocytes take part in the pathogenesis of many kinds of drug eruption. Histologically, drug eruption is characterized mainly by epidermal injury, and more and more evidence has suggested that epidermal T lymphocytes play a vital role in epidermal injury in drug eruption. This paper presents a concise description on the epitope, function, activation modulation, action pathway of epidermal T lymphocytes and their roles in drug eruption.

关 键 词：药疹 表皮 T淋巴细胞 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]