CD4＋CD25＋Treg与脓毒症患者细胞免疫紊乱之间的关系  

The Relationship between the Level of CD4＋CD25＋ Treg and Cell Immunity in Patients with Sepsis

作　　者：张丽娜[1] 吴铁军[1] 

机构地区：[1]聊城市人民医院ICU,252000

出　　处：《麻醉与监护论坛》2010年第1期32-35,共4页Forum of Anesthesia and Monitoring

摘　　要：目的：检测脓毒症患者外周血中CD4＋CD25＋Treg的比例（Treg％）变化．并探讨它和患者细胞免疫紊乱之间的关系。方法：收集ICU病房的脓毒症患者为病例组（n=27）．健康查体者为对照组（n=40）。将脓毒症患者根据28天预后分为死亡组（n=8）和存活组（n=19）。监测APACHEⅡ评分．Treg％、CD3％，CD4／CD8．Ag—NORs数量（IS％）等。以上指标各组进行比较．统计分析。结果：和对照组相比，病例组Treg％明显升高．CD3％，CD4／CD8、IS％明显下降．均有显著统计学意义（P〈0.001）。行相关分析发现脓毒症患者的Treg％和CD4／CD8，IS％呈负相关，分别有r=-0．484（P〈0．01）及r=-0．588（P〈0．01）。同样发现．死亡组和存活组相比．前者Treg％明显升高（P〈0．001），CD3％、CD4／CD8、JS％明显下降（分别有P〈0．001、P〈0．05．P〈0．001）。结论：脓毒症患者早期就有CD4＋CD25＋Treg的明显升高．并发生细胞免疫紊乱，因CD3％、CD4／CD8．IS％明显下降．升高的CD4＋CD25＋Treg通过一定途径参与细胞免疫功能紊乱的发生。Objective： To investigate the percentage of CD4＋CD25＋ Treg in peripheral blood of patients with sepsis and explore its effect on cell immunity. Metheds： Select patients with sepsis in ICU as case group （n=27） , healthy volunteers were enrolled as control group（n=40）. Devied the sepsis patients into death group and survival group depend on the outcome after 28 days .Detect APACHE Ⅱ score, Treg%, CD3%, CD4/CD8, IS% etc.Compared between assosiated groups. Progressed statistical analysis. Results： Compared with the control group . the percentage of CD4＋CD25＋ Treg was significant higher and the CD3%, CD4/CDs, IS% were significant lower in case group ,all had significant statistics significance（P 〈0.001）. Correlation analysis indicated that Treg%had negative correlation with CD4/CD8 IS%（P〈0.01）.Samely, Compared with the survival group, the percentage of CD4＋CD25＋ Treg was significant higher（P〈0.001） and the CD3%, CD4/CD8, IS% were significant lower （P〈0.001, P〈0.05, P〈0.001） in death group. Conlusion ： The percent of CD4＋CD25＋ Treg was significent higher and CD3%, CD4/CD8, IS% were lower which indected cell immunity disorder even in the earlier period of sepsis. The CD4＋CD25＋ Treg produced a marked effect on the development of cell immunity disorder.

关 键 词：脓毒症 调节细胞 细胞免疫 

分 类 号：R725.631[医药卫生—儿科]