水林佳治疗非酒精性脂肪性肝病疗效观察  

Clinical effect of silibinin capsule in patients with non-alcoholic fatty liver disease

作　　者：李立伟[1] 冯天娇[1] 陈文实[1] 

机构地区：[1]安徽省蚌埠市第三人民医院中西医结合科,233000

出　　处：《淮海医药》2010年第4期306-308,共3页Journal of Huaihai Medicine

摘　　要：目的观察水林佳(水飞蓟宾-磷脂复合物)治疗非酒精性脂肪性肝病的临床疗效。方法将56例患者随机分为2组,治疗组予水林佳口服,对照组予硫普罗宁口服,均3个月为1个疗程,疗程结束后,观察临床症状、ALT、AST、TC、TG和超声影像的变化。同时观察2组患者用药期间的不良反应。结果治疗组和对照组总有效率分别为89.3%及71.4%,治疗组明显高于对照组,2组比较差异有显著性(P<0.05)。治疗组在改善患者临床症状、肝功能、血脂及超声影像方面疗效确切,无明显不良反应。结论水林佳治疗非酒精性脂肪性肝病有较好临床疗效。Objective To observe the clinical efficacy of silibinin capsules in patients with non-alcoholic fatty liver disease（NAFLD）.Methods 56 patients with NAFLD were randomly divided into a treatment group treated with silibinin capsules and a control group treated with tiopronin tablets respectively for consecutive 3 months.Before and 12 weeks after the treatment,the changes of clinical symptom,serum transaminase level（ALT/AST）,cholestero（TC）,triglyceride（TG）and ultrasonic image were dectected respectively.Adverse effect was also observed during the experiment.Results The total effective rate in the treatment group was 89.3%,which was higher than that in the control group（71.4%）,showing significant difference statistically（P0.05）.Satisfactory effect was obtained in the improvement of clinical symptom,serum ALT/AST,TC,TG and ultrasonic image.No severe adverse effect occurred.Conclusion Silibinin capsule has significant therapeutic effect on NAFLD.

关 键 词：脂肪肝 水林佳 治疗结果 

分 类 号：R541.6[医药卫生—心血管疾病]