裂叶荆芥芥穗的化学成分研究  

Studies on the chemical constituents of the ear of Schizonepeta Mulifida

作　　者：刘巨涛[1,2,3] 杨智蕴[1,2,3] 景风英 

机构地区：[1]空军医学高等专科学校 [2]东北师范大学化学系 [3]中国科学院长春应用化学研究所

出　　处：《中国药学杂志》1999年第2期87-89,共3页Chinese Pharmaceutical Journal

摘　　要：目的：对裂叶荆芥［Ｓｃｈｉｚｏｎｅｐｅｔａｍｕｌｉｆｉｄａ（Ｌ．）Ｂｒｉｑ．］芥穗的化学成分析进行研究。方法：利用溶剂提取和硅胶、聚酰胺、活性炭柱层析进行分离。结果：得到３个化合物，根据化合物的理化性质和光谱数据鉴定其结构。其中１个为已知成分即脱氢枞油烯（ｄｅｈｙｄｒｏｓｙｌｖｅｓｔｒｅｎｅ，Ｖ），另２个为新成分，分别命名为新壬四酸（ｎｅｏｅｎｎｅａａｎｅｔｅｔｒａｏｉｃａｃｉｄ，Ⅶ）、３亚胺基Ｎ氮代乙酰胺基丁内酰胺（３ｉｍｉｎｏＮｎｉｔｒｏｇｅｎｓｕｂｓｔｉｔｕｔｅｄａｃｅｔａｍｉｄｏｃｙｃｌｉｃｂｕｔｙａｍｉｄｅ，Ⅷ）。结论：３个化合物均为首次从该植物中分得。另外还得到１个正高级烷烃混合物。OBJECTIVE:To investigate the chemical constituents of the ear of Schizonepeta mulifida (L.)Briq. METHODS:Ingredients of the ear of this plant were separated by means of solvent extraction and chromatography on silica gel and polyamide and activated charcoal. RESULTS:Three components were isolated. Their structures were elucidated based on the spectral analysis. One of them is a known compound i.e. dehydrosylvestrene (V). The other two were new compound,named neoenneaanetetraoic acid (Ⅶ),and 3 imino N nitrogen substituted acetamide cyclic buty amide (Ⅷ). CONCLUSION:These 3 compounds were isolated from the plant for the first time.By the way, a mixture of n alkane was also obtained which contains seventeen n alkane compounds proved by GC MS.

关 键 词：裂叶荆芥 枞油烯 新壬四酸 芥穗 

分 类 号：R284.1[医药卫生—中药学]