国产两性霉素B抢先治疗血液病患者肺部侵袭性真菌感染的疗效与安全性分析  

Efficacy and safety of domestic amphotericin B in preemptive therapy of pulmonary invasive fungal infection in hematological disorder patients

作　　者：柴俊月[1] 魏娜[1] 崔婷婷[1] 许兰平[2] 黄晓军[2] 

机构地区：[1]北京市第六医院血液科,北京100007 [2]北京大学人民医院血液病研究所,北京100044

出　　处：《中国真菌学杂志》2010年第3期144-147,共4页Chinese Journal of Mycology

基　　金：公益性行业科研专项(200802027)

摘　　要：目的观察国产两性霉素B抢先治疗血液病患者侵袭性肺部真菌感染(以下简称IFI)的疗效与不良反应。方法回顾性分析我院2004年12月～2008年12月间,45例免疫功能低下IFI患者接受国产两性霉素B治疗的临床资料。结果 45例患者均应用两性霉素B治疗两周以上,最长应用时间为14周,中位数6周。总有效率为86.7%,不良反应主要有低钾血症、发热、转氨酶升高、肾功损害、胃肠道反应,根据WHO药物毒性分级标准均为I～II级毒性。结论国产两性霉素B对于血液病患者IFI临床诊断的抢先治疗疗效肯定,不良反应可耐受。Objective To observe the therapeutic efficacy and adverse reactions of domestic amphotericin B in the treatment of invasive fungal infection （IFI） in hematological disorder patients. Methods A total of 45 cases of immunodepressive IFI patients receive domestic amphotericin B treatment from December 2004 to December 2008 in our hospital were retrospectively analyzed. Result All the cases patients received amphotericin B therapy for more than 2 weeks,in which the longest was 14 weeks,with 6 weeks as median. The total effective rate was 86. 7% . Adverse reaction included hypokalemia,fever,aminotransferase,kidney failure,and gastrointestinal reactions. Conclusions Domestic amphotericin B is affirmed in the preemptive therapy for IFI in hematological patients with tolerable adverse reactions.

关 键 词：两性霉素B 血液病 侵袭性真菌感染 抢先治疗 

分 类 号：R756.6[医药卫生—皮肤病学与性病学]