肠促胰素与骨代谢  

Incretin and bone metabolism

作　　者：鲍洁[1] 金晖[1] 

机构地区：[1]东南大学附属中大医院内分泌科,南京210009

出　　处：《中国骨质疏松杂志》2010年第7期521-524,共4页Chinese Journal of Osteoporosis

摘　　要：机体内不断进行着骨代谢转换。凡是能增加骨吸收、减少骨生成的因素均能使骨密度(BMD)下降,进而发生骨质疏松症(OP)。最新研究发现,人体胃肠道内分泌的肠促胰素,不仅能促进胰岛素释放、调节血糖代谢,对骨代谢转换过程也具有良好的调节作用。这类肠促胰素包括葡萄糖依赖性胰岛素释放肽(GIP)、胰高血糖素样肽-1(GLP-1)和胰高血糖素样肽-2(GLP-2)。它们对骨代谢的作用主要通过相应的受体来完成,达到调节钙平衡、影响破骨细胞和成骨细胞的增生与凋亡、影响其他骨代谢生化指标等目的。其中,GIP、GLP-1均有减少骨吸收和增加骨生成的双相调节作用,而GLP-2仅能抑制骨的吸收,而不影响骨的生成。肠促胰素的这些特性,将为骨质疏松现有的治疗模式发展出新的方向。Bone turnover occurs constantly in humans. Factors that increase bone resorption and decrease bone formation could reduce bone mineral density （BMD）, resulting in osteoporosis （OP）. Recent studies show that incretin hormones, secreted from gastrointestinal tract, could promote excreting insulin, regulating glycomeabolism, even affecting the process of whole bone turnover. Incretins include Glucose-dependent insulinotropic peptide （ GIP ） , Glucagon-like peptide-1 and Glucagon-like peptide-2 （ GLP-2 ）. These hormones perform function to regulate bone metabolism mainly through their receptors, aiming to affect calcium homeostasis, proliferation and apoptosis of the osteoblasts and osteoelasts, and other biochemical parameters of bone turnover. Both GIP and GLP-1 could regulate bone metabolism by inhibiting bone absorption and stimulating bone formation. However, GLP-2 could only inhibit bone absorption, but has no influence to bone formation. The study of the property of incretins could produce a new direction for the treatment of osteoporosis in future.

关 键 词：骨代谢 葡萄糖依赖性胰岛素释放肽 胰高血糖素样肽-1 胰高血糖素样肽-2 

分 类 号：R587[医药卫生—内分泌]