犊牛脾脏低分子提取物抗肿瘤作用研究  

Antitumor Effects of the Low Molecular Extract from Calf Spleen

作　　者：陈清华[1] 李红[2] 肖殿宽[1] 王铁 

机构地区：[1]辽宁医学院实验动物中心,辽宁锦州121001 [2]辽宁医学院基础学院,辽宁锦州121001 [3]辽宁省锦州奥鸿药业,辽宁锦州121001

出　　处：《安徽农业科学》2010年第16期8460-8461,共2页Journal of Anhui Agricultural Sciences

摘　　要：[目的]研究犊牛脾脏提取物的体内抗肿瘤活性。[方法]采用超滤和离心技术制备脾脏提取物,选取移植型S180荷瘤小鼠为动物模型,腹腔注射脾提取物,观察小鼠存活时间,并计算抑瘤率。[结果]脾脏提取物显著增加S180荷瘤小鼠的存活率,并抑制肿瘤的生长,治疗第15天,最高抑瘤率达到61%。[结论]脾脏提取物是一种分子量小且安全有效的抗肿瘤活性物质。[Objective] To study the antitumor activity of the extract from calf spleen in vivo.[Method] The spleen extract was prepared with technologies of ultrafiltration and centrifugation.S180-bearing mice act as animal models that were treated with intraperitoneal injection of the extract,and survival time of mice was observed and inhibition rate was calculated.[Result]The spleen extract significantly prolonged the survival period of the S180-bearing Kunming mice and inhibited the growth of S 180-cells.The tumor inhibition rate was up to 61%.[Conclusion] The spleen extract is a safe,effective and low molecular weight tumor suppressor.

关 键 词：犊牛 脾脏 低分子抑瘤物 抗肿瘤作用 

分 类 号：S852[农业科学—基础兽医学]