DAZ基因外显子与无精子症的关系  

THE RELATIONSHIP BETWEEN DAZ EXON AND AZOOSPERMIA

作　　者：王恒才[1] 路西兰[1] 侯孟彦[1] 张迎春[1] 王红霞[1] 张意茗[1] 

机构地区：[1]山东大学附属济南市中心医院生殖医学科,山东济南250013

出　　处：《青岛大学医学院学报》2010年第5期455-456,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨Y染色体无精子缺失(DAZ)基因外显子与无精子症的关系。方法应用多重聚合酶链反应(PCR)技术对97例无精子症病人和60例正常生育男性DAZ基因外显子进行检测。结果 97例无精子症病人DAZ基因外显子缺失4例,缺失率4.12%,正常生育男性DAZ外显子未检测到缺失。结论 DAZ基因外显子缺失可导致无精子症;检测不育病人是否有Y染色体微缺失,对于通过辅助生殖技术(ART)将这种基因缺陷遗传给下一代的可能性评估具有重要意义。Objective To explore the relationship between DAZ exon in Y chromosome and azoospermia.MethodsDAZ exons were detected by polymerase chain reactions（PCR）in 97 patients with azoospermia and 60 normal men.Results Of 97 patients,DAZ exon deletion was found in four（4.12%）.However,DAZ exon deletion was not found in the healthy subjects.Conclusion Deletion of DAZ exon may result in azoospermia.A detection of whether an infertile patient is suffering from Y microdeletion is of great importance to assess the possibility of descending this gene defect to offspring through assisted reproductive technology.

关 键 词：少精子症 Y染色体 DAZ外显子 聚合酶链反应 不育 男(雄)性 

分 类 号：R698.2[医药卫生—泌尿科学]