鼻塞式同步间歇指令通气和持续气道正压通气在早产儿呼吸窘迫综合征中的应用比较  

Randomized trail of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome

作　　者：高薇薇[1] 谭三智[2] 陈运彬[1] 张永[1] 王越[1] 

机构地区：[1]广东省妇幼保健院新生儿科,广东广州510010 [2]广州市第一人民医院急诊科,广东广州510050

出　　处：《中国当代儿科杂志》2010年第7期524-526,共3页Chinese Journal of Contemporary Pediatrics

基　　金：广东省自然科学基金(06019787);广东省医学科学技术研究基金资助项目(A2008088);广东省科技计划项目(2007B03150009)

摘　　要：目的比较鼻塞式同步间歇指令通气(nSIMV)和鼻塞式持续气道正压通气(nCPAP)在早产儿呼吸窘迫综合征(RDS)中的临床应用效果。方法 50例RDS早产儿,常规使用肺表面活性物质进行替代治疗后,随机分入nSIMV组或nCPAP组,观察治疗后临床症状和血气指标的变化。结果 nSIMV组需气管插管行呼吸机通气比率明显低于nCPAP组(24%vs60%,P<0.05);nSIMV组CO2潴留和低氧血症的比率分别为12%和24%,明显低于nCPAP组的40%和36%(P<0.05)。结论 nSIMV能更有效地对RDS早产儿进行呼吸支持治疗。Objective To compare the efficacy of nasal synchronized intermittent mandatory ventilation（nSIMV） and nasal continuous positive airway pressure（nCPAP） in preterm infants with respiratory distress syndrome（RDS）.Methods Fifty preterm infants with RDS who received pulmonary surfactant were randomized to nSIMV and nCPAP groups after extubation.Clinical signs,symptoms and blood gas results following nSIMV or nCPAP were compared in the two groups.Results Compared with the nCPAP group,the nSIMV group had a lower incidence of failure respiratory support（24% vs 60% ;P〈0.05）,a lower incidence of hypercarbonia（12% vs 40% ;P〈0.05） and a lower incidence of hypoxia（24% vs 36% ;P〈0.05）.Conclusions nSIMV is more effective in respiratory support in preterm infants with RDS.

关 键 词：呼吸窘迫综合征 鼻塞式持续气道正压通气 鼻塞式同步间歇指令通气 早产儿 

分 类 号：R722.6[医药卫生—儿科]