含有偶氮苯基的水溶性共聚物包覆的脂质体的光控释放行为  

PHOTOCONTROLLED RELEASE BEHAVIOR OF LIPO SOMES COATED WITH A WATER SOLUBLE COPOLYMER CONTAINING AZOBENZENE GROUPS

作　　者：史向阳[1,2] 孙曹民[1,2] 吴世康[1,2] 

机构地区：[1]中国科学院感光化学研究所 [2]北京理工大学生物材料实验室

出　　处：《感光科学与光化学》1999年第1期38-44,共7页Photographic Science and Photochemistry

基　　金：国家自然科学基金

摘　　要：为了研究侧链含有偶氮苯基的水溶性共聚物的光异构化对脂质体内包容物的光控释放的影响，设计合成了Ｎ－异丙基丙烯酰胺（ＮＩＰＡＭ）和丙烯酰胺基偶氮苯（ＡＡＡＢ）的共聚物．以５（６）－羧基荧光素（５（６）－ＣＦ）为水溶性标记物，研究了共聚物包覆的小单层脂质体（ｓｍａｌｕｎｉｌａｍｅｌａｒｖｅｓｉｃｌｅｓ，ＳＵＶ）在室温２５℃时的释放行为．研究发现，在波长大于３５０ｎｍ的光源照射下，共聚物包覆的脂质体中５（６）－ＣＦ的释放速率明显提高，证明侧链含有偶氮苯基的水溶性共聚物包覆的脂质体具有明显的光控释放性能．并对此现象作了讨论．The copolymer of N isopropylacrylamide (NIPAM) and acrylamido azobenzene (AAAB) was synthesized for the study of the effect of the photoisomerization of a water soluble copolymer containing azobenzene groups on the photocontrolled release behavior of liposomes. The release property of small unilamellar vesicles(SUV) coated with the copolymer was studied at 25℃ by using 5(6) carboxyfluorescein (5(6) CF) as a water soluble marker. Results showed that under photoirradiation, the release of 5(6) CF from liposomes coated with the copolymer containing azobenzene groups was remarkably increased and exhibits an obvious photocontrolled release property. This phenomenon was discussed preliminarily.

关 键 词：水溶性高分子 脂质体 光控释放 共聚物 光学性 

分 类 号：O631.24[理学—高分子化学] O644.14[理学—化学]