一种双链季铵盐消毒剂杀菌效果与毒性观察  

GERMICIDAL EFFICACY AND TOXICITY EVALUATION OF A GEMINI QUATERNARY AMMONIUM SALT

作　　者：苏鑫[1,2] 王碧清[1] 赵晓蕾[3] 冯玉军[1] 

机构地区：[1]中国科学院成都有机化学研究所,成都610041 [2]中国科学院研究生院 [3]南京理工大学化工学院

出　　处：《中国消毒学杂志》2010年第4期383-385,共3页Chinese Journal of Disinfection

基　　金：中科院成都分院抗震救灾专项(防疫用新型高效广谱消毒杀菌剂的研究与开发);中国科学院成都教育基地科技救灾专项社会实践后续资助项目(利用活性自由基聚合制备新型广谱消毒杀菌剂)

摘　　要：目的观察一种双链季铵盐消毒剂杀菌效果及其毒性。方法采用悬液定量杀菌试验和动物毒性试验进行实验室观察。结果用含100 mg/L的该双链季铵盐消毒剂对悬液内金黄色葡萄球菌作用5 min,平均杀灭对数值>5.00。含量为2 000 mg/L的该双链季铵盐消毒剂对悬液内大肠杆菌作用10 min,平均杀灭对数值>5.00。含量为5 000 mg/L的该双链季铵盐消毒剂对悬液内白色念珠菌作用15 min,平均杀灭对数值>4.00。该双链季铵盐消毒剂对小鼠急性经口毒性试验LD50>5 000 mg/kg体重,属于实际无毒级。结论该双链季铵盐消毒剂对细菌繁殖体具有较好的杀灭效果,对真菌杀灭所需浓度较高,属于无毒物质。Objective To examine the germicidal efficacy and toxicity of a gemini quaternary ammonium salt disinfectant.Methods Suspension quantitative germicidal test and toxicity test were used for laboratory evaluation.Results The average killing logarithm values of Staphylococcus aureus in suspension exposed to the solution of the disinfectant containing gemini quaternary ammonium salt 100 mg/L for 5 min was above 5.00.The average killing logarithm values of Escherichia coli in suspension containing gemini quaternary ammonium salt 2 000 mg/L for 10 min was above 5.00.The average killing logarithm values of Candida albicans in suspension containing gemini quaternary ammonium salt 5 000 mg/L for 15 min was above 4.00.The mouse acute oral LD50 of the disinfectant was higher than 5 000 mg/kg body weight,which belonged to non-toxic class.Conclusions The gemini quaternary ammonium disinfectant has good germicidal efficacy to vegetative forms of bacteria.It need higher germicidal concentration to fungus,and it belongs to non-toxic class.

关 键 词：双链季铵盐 细菌繁殖体 真菌 杀菌效果 毒性 

分 类 号：R187.2[医药卫生—流行病学]