重组人神经营养因子-4/5蛋白抗砷、汞神经毒作用的初步研究  

The Prelimilary Study on the Anti neurotoxic Effects of Recombination Protein of Human Neurotrophin 4/5 on As 2O 3 and HgBr 2

作　　者：楼屹[1,2,3] 王国荃[1,2,3] 殷明 戴建凉[1,2,3] 应康 顾少华 刘建平[1,2,3] 谢毅 

机构地区：[1]上海第二医科大学仁济医院 [2]新疆医科大学环境卫生教研室 [3]上海复旦大学遗传工程国家重点实验室

出　　处：《环境与健康杂志》1999年第2期77-79,共3页Journal of Environment and Health

摘　　要：为观察重组ｈＮＴ－４／５蛋白对三氧化二砷（Ａｓ２Ｏ３）、溴化汞（ＨｇＢｒ２）毒性的抑制作用。将具有天然蛋白活性的重组ｈＮＴ－４／５蛋白，加入到被不同浓度的Ａｓ２Ｏ３、ＨｇＢｒ２染毒的各组鸡胚前脑神经细胞培养液中共同孵育，结果表明对照组与实验组的细菌存活数差异有显著性（Ｐ＜０．０１、Ｐ＜０．０５），说明重组ｈＮＴ－４／５蛋白具有抑制Ａｓ２Ｏ３。The study explored the anti neurotoxic effects of recombination protein of human neurotrophin 4/5(hNT 4/5) on As 2O 3 and HgBr 2 The culture medium of forebrain nerve cells from embryonic chicken added with natural active recombin ation hNT 4/5 protein, treated with different levels of As 2O 3 and HgBr 2 respectively,was incubated The results showed that significant differences of the amount of the surviral rates of the forebrain nerve cells from embryonic chicken between the control group and experimental group( P<0 01,P<0 05 ) were found It indicated that the recombination hNT 4/5 could inhibit the toxicity of As 2O 3 and HgBr 2

关 键 词：神经营养因子 三氧化二砷 溴化汞 神经毒作用 

分 类 号：X838[环境科学与工程—环境工程] R994.6[医药卫生—毒理学]