乳化溶剂扩散-吸附法制备肺靶向ADM-PLGA微球  

Preparation of Lung Targeting Adriamycin-PLGA Microspheres by Emulsion Solvent Diffusion

作　　者：罗斌华[1,2] 赵志娟[1] 丁红[1] 阎志飞[1] 赵智卉[1] 

机构地区：[1]山西医科大学药学院,山西太原030001 [2]湖北咸宁学院药学院,湖北咸宁437100

出　　处：《中国现代医生》2010年第18期88-89,106,共3页China Modern Doctor

基　　金：山西省教育厅科技研究基金(晋教科2003019);山西医科大学青年基金(NO.02200809)

摘　　要：目的制备阿霉素(ADM)-乳酸-羟基乙酸共聚物(PLGA)微球并考察其特性。方法选用生物可降解的乳酸-羟基乙酸共聚物为载体材料,采用乳化溶剂扩散-吸附法制备ADM-PLGA微球。结果制备的微球外观圆整,粒径范围在7～20μm,占90.07%,载药量为5.93%,包封率为38.3%。结论该法制备的微球粒径和载药量符合肺靶向ADM-PLGA微球要求。Objective To prepare and investigate lung targeting adriamycin -PLGA （ADM-PLGA） microspheres and their characteristics. Methods ADM-PLGA microspheres were prepared by emulsion solvent diffusion-adsorbed method with biodegradable PLGA as core material. Results ADM-PLGA microspheres were spherical and regular in morphology, the diameters of 90.1% mierospheres were in the range of 7-20μm, the loading amount was 5.93% and the entrapment rate was 38.3%. Conclusion The particle size and drug-loading amount are fit for the requirement of lung targeting ADM-PLGA microspheres by using the preparation.

关 键 词：阿霉素 PLGA 微球 乳化溶剂扩散-吸附法 

分 类 号：R979.14[医药卫生—药品] R944[医药卫生—药学]