反相高效液相色谱法测定吉非替尼的含量  

Quantitative Determination of Gefitinib in Iresa by Reversed-phased High Performance Liquid Chromatography

作　　者：钟延霞[1] 陈艳雪[1] 王宝君[1] 

机构地区：[1]石家庄医学高等专科学校基础部,河北石家庄050073

出　　处：《河北师范大学学报（自然科学版）》2010年第4期453-454,458,共3页Journal of Hebei Normal University：Natural Science

基　　金：河北省自然科学基金(B2005000151)

摘　　要：建立了高效液相色谱法测定吉非替尼的方法,吉非替尼的质量为6.824 0-34.120 0μg时线性关系良好,线性系数为0.999 08.加标回收率大于95%,检测底限为20.724 8μg.该方法简单、快速、可靠、方便,可用于吉非替尼含量的测定.Gefitimbin was quantitatively determined by reversed-phased high performance liquid chromatography.There was a good linear relationship with the range of 6.824 0～34.120 0 μg（r=0.999 08）.The recovery was more than 95 %.The detection limit was 20.724 8 μg.The method was rapid,simple,accurate and convenient.The method could be used for the determination of gefitinib.

关 键 词：反相高效液相色谱 测定 吉非替尼 

分 类 号：O657.72[理学—分析化学] TQ460.72[理学—化学]