天津市农村地区良性前列腺增生症危险因素分析  

Risk factors analysis of benign prostatic hyperplasia in the suburb of Tianjin

作　　者：刘妍[1,2] 田心[1] 徐勇[3] 杨阔[2] 郭晓磊[2] 雷铭德[2] 

机构地区：[1]天津医科大学,天津300070 [2]天津市泌尿外科研究所 [3]天津医科大学第二医院

出　　处：《山东医药》2010年第22期4-5,共2页Shandong Medical Journal

基　　金：天津市科技计划资助项目(07ZCGYSF01000);天津市科技攻关项目(2007KG06);天津市卫生局科技基金资助项目(06KZ28)

摘　　要：目的探讨天津市农村地区50岁以上男性良性前列腺增生症(BPH)的相关危险因素。方法调查210例天津市农村50岁以上男性BPH患者(观察组)和210例体检前列腺正常者(对照组)的一般情况、慢性病主要危险因素、家族史、个人健康状况和生化指标(包括血浆睾酮、前列腺特异性抗原和血脂)。采用条件Logistic回归分析法筛选出前列腺增生相关的影响因素,并进行单因素和多因素分析。结果单因素分析发现男性BPH与年龄、前列腺内钙化、血浆睾酮、饮食规律性、血浆高密度脂蛋白水平、化肥接触史、血浆低密度脂蛋白水平、受教育程度、体力劳动、家庭年收入情况、辛辣刺激饮食、30岁时的性生活频率等有关(P均<0.05);多因素分析结果显示婚姻情况复杂、教育程度高、有化肥接触史、家庭年收入高、30岁时性生活频率高、血浆低密度脂蛋白水平高增加BPH的风险(OR分别为1.817、1.220、1.824、1.411、1.191、1.855);总胆固醇高为BPH的保护性因素(OR为0.490)。结论天津市农村地区男性BPH的相关危险因素是婚姻情况复杂、教育程度高、有化肥接触史、家庭年收入高、30岁时的性生活频率高、低密度脂蛋白高。Objective To investigate the risk factors of benign prostatic hyperplasia（BPH） in the suburb of Tianjin. Methods A male population based ease-control study over 50 years old in the suburb of Tianjin was conducted. Survey on diet,questionnaire regarding health and lifestyle and related blood indexs were studied and tested about eases with 1 ： 1 matched controls. Logistic regression models were used to select risk factors. Results 210 cases and 210 controls were in- terviewed. Research data through univariate analysis showed that the occurrence of BPH were associated with age, prostate calcification, the concentration of testosterone in serum, spicy food, the frequent of sex life at 30 years old, annual average income, dietary regularity, ehemical contacthistory, educational level, physical work, the concentration of high density lipoprotein in serum and the concentration of low density lipoprotein in serum （ P 〈 0.05 ）. As shown in multivariable logistie model, some factors, including chemical contacthistory （ OR = 1. 824 ）, the frequency of sex life at 30 years old （ OR = 1. 191 ）, annual average income（ OR = 1. 411 ） ,education（ OR = 1. 220）, marital status（ OR = 1. 817） and low density lipoprotein（ OR = 1. 855 ） could increase the risk of BPH. Total cholesterol was an protective factor of BPH （ OR = 0.490 ）. Conclusion Chemical eontaethistory, the frequency of sex life at 30 years old, annual average income, education , marital status, total cholesterol, low density lipoprotein are related to subjects with BPH in the suburb of Tianjin. The incidence of BPH could be effectively reduced by changing the unhealthy lifestyle and curing the patient with the disease.

关 键 词：前列腺增生 危险因素 病例对照研究 

分 类 号：R697[医药卫生—泌尿科学]