大剂量IVIG、PP联合小剂量IVIG对高致敏肾移植受者脱敏效果比较  

Hyposensitization effect comparison of high-dose IVIG and low-dose IVIG united with plasmapheresis in high sensitization renal transplantation recipients

作　　者：郭娟[1] 曲青山[1] 朱明慧[1] 

机构地区：[1]郑州人民医院,郑州450003

出　　处：《山东医药》2010年第22期8-9,共2页Shandong Medical Journal

摘　　要：目的观察并比较大剂量静注免疫球蛋白(IVIG)和血浆置换(PP)联合小剂量IVIG对高致敏肾移植受者脱敏的效果。方法高致敏肾移植受者28例,随机分为观察组15例和对照组13例。观察组采用PP联合小剂量IVIG静注,对照组采用大剂量IVIG静注脱敏。结果脱敏后对照组4例、观察组9例群体反应性抗体(PRA)下降,肾移植术l a后11、6例PRA反弹。两组PRA下降率和反弹率相比P均<0.05。对照组敏感者中4例、观察组6例发生急性排斥反应,两组急性排斥反应发生率相比P<0.05。结论与单用大剂量IVIG静注相比,PP联合小剂量IVIG静注能更有效降低高致敏肾移植受者PRA水平,降低术后急性排斥反应发生率。Objective To observe the hyposensitization effect comparison of high-dose IVIG and low-dose IVIG united with plassmapheresis in high sensitization renal transplantation recipients. Methods 28 high sensitization renal transplantation recipients were divided into observe group（ 15 cases） and control group（ 13 cases）. Low-dose IVIG and plasmapheresis were used in observe group and high-dose IVIG was used in control group. Results The PRA level of 9 cases in observe group and 4 cases in control group decreased. The PRA level of 6 cases in observe group and 11 cases in control group rebounced one year after renal transplanation. Acute rejection emerged in 4 cases in control group and 6 cases in observe group. Coneludion Conpared with high-dose IVIG, low-dose IVIG and plasmapheresis can decrease the PRA level and acute rejection rate effectively.

关 键 词：肾移植 免疫球蛋白 血浆置换 急性排斥反应 

分 类 号：R692[医药卫生—泌尿科学]