α-葡萄糖苷酶抑制剂Radicamine A的合成  

Synthesis of Radicamine A as a α-glucosidase inhibitor

作　　者：刘春艳[1] 孟爱国[2] 

机构地区：[1]华北煤炭医学院药学系,河北唐山063000 [2]华北煤炭医学院附属医院,河北唐山063000

出　　处：《化学研究与应用》2010年第7期911-914,共4页Chemical Research and Application

基　　金：河北省自然科学基金(C2010001761)资助项目

摘　　要：Radicamine A was prepared via a key intermediate-cycle nitrone 5 by using D-arabinose as the raw material with a total yield of 15.5%.Cycle nitrone 5 was synthesized by protection of hydroxyl group,introduction of nitrogen and intromolecular cyclization.And then it had a high stereoselective addition reaction with aryl Grignard reagents 6 to form compound 7.Finally,the target compound was obtained by catalytic hydrogenation of compound 7.The novel compounds 3 and 4 were confirmed by 1HNMR,IR,MS and elemental analysis.Radicamine A was prepared via a key intermediate-cycle nitrone 5 by using D-arabinose as the raw material with a total yield of 15.5%.Cycle nitrone 5 was synthesized by protection of hydroxyl group,introduction of nitrogen and intromolecular cyclization.And then it had a high stereoselective addition reaction with aryl Grignard reagents 6 to form compound 7.Finally,the target compound was obtained by catalytic hydrogenation of compound 7.The novel compounds 3 and 4 were confirmed by 1HNMR,IR,MS and elemental analysis.

关 键 词：Radicamine A Α-葡萄糖苷酶抑制剂 环状硝酮 合成 

分 类 号：O629.3[理学—有机化学]