铁氰化钾-三氯化铁显色体系分光光度法测定特布他林  

Spectrophotometric determination of terbutaline using K_3[Fe(CN)_6]-FeCl_3

作　　者：郑立庆[1] 李晶[1] 范顺利[1] 高林晓[1] 李全民[1] 

机构地区：[1]河南师范大学化学与环境科学学院,河南省环境污染控制重点实验室,河南新乡453007

出　　处：《化学研究与应用》2010年第7期961-964,共4页Chemical Research and Application

基　　金：河南省基础与前沿技术研究计划项目(082300420150,092300410238)

摘　　要：特布他林（间羟舒喘灵，Terbutaline，TB）系一种选择性β2受体激动剂，有松弛支气管平滑肌，抑制内源性痉挛物质的释放及内源性介质引起的水肿等功能。临床上已广泛用于治疗支气管哮喘、慢性支气管炎、肺气肿和其它伴有支气管痉挛的肺部疾病。已报道测定特布他林的方法有色谱法。A novel and simple spectrophotometric method for the determination of terbutaline with potassium ferricyanide as a chromogenic reagent is established in this paper.It is based on the fact that Fe（III）is reduced to Fe（II）by terbutaline at pH 4.00 in the presence of potassium ferricyanide and Fe（II）reacts with potassium ferricyanide to form the dissoluble prussian blue.Beer＇s law is obeyed in a range of 0.06 ~ 8 μg·ml-1.The equation of linear regression is A=0.05417＋0.15575C（μg·mL-1）,with a linear correlation coefficient of 0.9988.The molar absorption coefficient is 8.5×104 L·mol-1·cm-1.The detection limit is 0.04 μg·mL-1,and the recovery rate is in the range of 99.0% ~ 102.7%.Furthermore,the method has been validated and successfully applied to the determination of terbutaline in pharmaceutical samples.

关 键 词：特布他林 铁氰化钾 分光光度法 

分 类 号：O657.32[理学—分析化学]