补肾通络中药对去卵巢大鼠骨丢失的抑制作用  

Inhibitory Effect of Kidney-invigorating and Meridian-dredging Chinese Herbal Medicine on Bone Loss in Ovariectomized Rats

作　　者：林一峰[1] 梁祖建[1] 何铭涛[1] 张百挡[1] 直彦亮[1] 

机构地区：[1]广州中医药大学药第三附属医院,广州510240

出　　处：《中药新药与临床药理》2010年第4期360-362,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省自然科学基金项目(815104701000050)

摘　　要：目的观察补肾通络中药对去卵巢大鼠骨丢失的抑制作用。方法将60只雌性SD大鼠随机分为3组:假手术组、模型组、补肾通络中药组,采用摘除双侧卵巢法建立大鼠骨质疏松模型,于术后1个月开始给药,连续给药3个月,观察补肾通络中药对去卵巢骨质疏松大鼠骨密度、骨生物力学及骨代谢相关血清生化的影响。结果 3个月后,补肾通络中药可显著增加大鼠股骨与腰椎的骨密度(0.153±0.012 g/cm2,0.187±0.012/g/cm2)、改善股骨骨生物力学(153.2±13.5/N,361.3±21.1/N.mm-1,44.1±9.6/mJ)及腰椎骨生物力学(193.3±23.1/N,765.1±83.3/N.mm-1,42.3±8.5/mJ),同时提高血清ALP的水平(198.9±7.7/U.L-1)。结论补肾通络中药可提高去卵巢实验性骨质疏松大鼠的骨密度、骨生物力学及血清ALP的水平,有明显的治疗骨质疏松作用。Objective To observe the inhibitory effect of kidney-invigorating and meridian-dredging Chinese herbal medicine （KMCHM）on bone loss in ovariectomized rats sham-operation group, model group and KMCHM group Methods Sixty female SD rats were divided into 3 groups： We established rat osteoporotic model by removing the bilateral ovaries. One months after the operation, KMCHM was given to the model group for 3 continuous months, and then we observed the effect on bone mineral density （BMD）, bone biomechanics （BB）and bone metabolism-related serum biochemical parameter after treatment. Results After treatment, KMCHM significantly enhanced BMD of femur and lumbar vertebrae （0.153±0.012 g/cm2 and 0.187±0.012/g/cm2 respectively）, and improved BB of femur （153.2± 13.5/N, 361.3±21.1/N·mm-1, 44.1±9.6/mJ ）and BB of lumbar vertebrae （193.3±23.1/N, 765.1±83.3/N·mm-1, 42.3± 8.5/mJ）. At the same time, KMCHM elevated the serum level of alkaline phosphatase （ALP）（198.9±7.7/U·L^-1）. Conclusion KMCHM can increase BMD, improve BB and elevate the serum ALP level, showing an obvious therapeutie effect on osteoporosis.

关 键 词：补肾通络中药 骨质疏松症 骨密度 生物力学 大鼠 

分 类 号：R285.5[医药卫生—中药学]