析因试验设计在剖宫产术预防感染用药研究中的应用  

Application of Factorial Design on Study of Using Drugs for Preventing Postoperative Infections of Cesarean Sections

作　　者：廖晓玲[1] 高清花[1] 李冠雄 徐彬[1] 梁佩洪[1] 孙宝峥 王强武[1] 周荣向[1] 孙成玲[1] 

机构地区：[1]海军421医院

出　　处：《中国药房》1999年第2期83-85,共3页China Pharmacy

摘　　要：目的：对剖宫产术预防感染用药进行前瞻性研究，为选择合理的给药方案提供依据。方法：采用３ｘ２ｘ３析因试验设计，分为因素和水平各不相同的１８种组合（即１８种给药方案）。５４例非择期性剖宫产随机分组，每一方案重复３次，监测临床感染性指标。结果：（１）全部病例无一发生术后感染性并发症；（２）伤口愈合等级均为甲级；（３）对于体温、血象等观察指标，在某些因素和水平间存在着显著性差异及交互作用。结论：（１）可采用单品种、短疗程预防感染。常规用药首选氨苄西林，个性粒细胞偏高者可选用头孢三嗪，以术中给药、３日疗程为优；（２）析因试验设计可为给药方案的优选提供一种好方法。OBJECTIVE: A prospective study on drug-use for preventing postoperative infections of cesarean section wascarried out in order to provide a basis for selection of drug administration scheme METHODS:Using 3 × 2× 3 factorial design ,we designed 18 schemes with different administration factors and levels. 54 cases undergoing cesarean section were randomlydivided into groups and each group received one scheme with three repetitions. clinical indices for infection were observed.RESULTS: ( 1) No postoperative infectious complications occurred in all groups. (2) All wounds healed in grade A. (3) Thereexisted significant differences or interaction effects between some factors or levels in patients'temperature and hemogram.CONCLUSION:( 1)For preventing infection , a scheme of single drug and short course may be adopted . As a routine , ampicillinis the first choice of drugs and in case of neutrophilic granulocytosis, ceftriaxone may be given. Intra-operative plus 3-daypostoperative administration is better than other schemes. (2) Factorial design is a good method for optimizing drug adminis-tration scheme.

关 键 词：析因设计 抗生素 剖宫术 合理用药 感染预防 

分 类 号：R978.1[医药卫生—药品] R719.1[医药卫生—药学]