不同原因致家兔实验性肺水肿动物模型的对比研究  

Comparative study on pulmonary edema rabbit models induced by different ways

作　　者：陈德森[1] 郭俐宏[2] 吴胜英[1] 

机构地区：[1]郧阳医学院机能实验室,十堰442000 [2]郧阳医学院附属太和医院针灸科

出　　处：《山西医科大学学报》2010年第7期655-657,共3页Journal of Shanxi Medical University

摘　　要：目的寻找一种能较好符合临床肺水肿病理生理特征的实验性肺水肿动物模型。方法 28只家兔随机分为油酸组、肾上腺素组、切断颈部两侧迷走神经组及生理盐水(NS)组,每组7只。测量家兔动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、肺泡-动脉氧分压差值(A-aPO2)、心率、呼吸频率、肺系数及死亡时间。结果油酸复制肺水肿动物模型中PaO2、PaCO2、A-aPO2、心率、呼吸频率、肺系数指标明显优于其他组,而死亡时间则低于肾上腺素复制模型。结论油酸复制肺水肿动物模型更接近真实的临床肺水肿,在实验性肺水肿动物模型中可考虑首选方案。Objective To seek out a better method to induce an ideal experimental animal model whose pathophysiological characteristics are more similar to the clinical pulmonary edema. Methods Rabbits were divided into oleic acid group,epinephrine group,vagus nerve cut-off group（ cut off the vagus nerve in both sides of the neck） and normal saline（ NS） group. Arterial blood oxygen pressure （ PaO2） ,arterial carbon dioxide pressure（ PaCO2） ,alveolar-arterial oxygen difference（ A-aPO2） ,respiratory frequency,heart rate,lung index and the time of death were measured. Results PaO2,PaCO2,A-aPO2,heart rate,respiratory frequency,and lung index were much better in oleic acid-induced model rabbits than that in rabbits induced by the other ways. Conclusion The experimental pulmonary edema rabbit model induced by oleic acid is more close to the features of clinical pulmonary edema,and would be considered as a preferred option.

关 键 词：动物模型 肺水肿 肾上腺素 迷走神经 油酸 家兔 

分 类 号：R563[医药卫生—呼吸系统]