静脉注射用纳米混悬剂  

Nanosuspensions for intravenous injection

作　　者：吴大鹏 陶涛 

机构地区：[1]上海现代药物制剂工程研究中心有限公司,上海201203

出　　处：《药学服务与研究》2010年第3期161-165,共5页Pharmaceutical Care and Research

基　　金："十一五"重大新药创制专项课题(No.2008ZX09201-006)

摘　　要：使用传统的制剂技术难以将高通量筛选技术筛选出的难溶于水的化合物开发成药物产品,将该类药物制备成纳米粒是一个很有前景的方法。纳米粒静注给药不仅能提高药物溶解度,还具有给药体积小等优点,因而药物静注纳米混悬剂的研发日趋增多。本文对静注纳米混悬剂开发过程中的制剂问题、安全性问题及其在临床上的应用做一综述。Poorly-water-soluble compounds screened by high throughput technology are difficult to be developed into drug products by conventional formulation techniques.The formulation of nanoparticle drugs has emerged as a promising strategy.Nanoparticles not only enhance the solubility of drug,but also lower the volume of injection.These have led to increasing research and development activities for intravenous nanosuspensions.This article reviews various challenges associated with development of intravenous nanosuspensions,including formulation techniques,safety issues and its clinical application.

关 键 词：剂型 纳米技术 混悬剂 工艺学 制药 输注 静脉内 表面活性剂 综述 

分 类 号：R944.1[医药卫生—药剂学]