1.5T场强MR动脉自旋标记灌注成像在脑梗死中的初步应用  

Preliminary application of arterial spin labeling perfusion 1.5T MR imaging for cerebral infarction

作　　者：刘永光 徐坚民 龚静山 李莹 朱进 张景忠 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院放射科,广东518020

出　　处：《放射学实践》2010年第7期733-736,共4页Radiologic Practice

基　　金：深圳市重点专科经费资助;深圳市医学重点学科建设项目(2001B07)

摘　　要：目的:探讨采用1.5T场强MR动脉自旋标记灌注成像(ASL-PWI)评价脑梗死的可行性。方法:对34例临床和MRI发现脑梗死的患者行常规MRI、扩散加权成像(DWI)及ASL-PWI扫描,根据Adamas分类将急性脑梗死分为大面积和小面积2组,比较DWI和ASL-PWI上病变的范围,比较病变区CBF值(CBF病变)与对侧正常区CBF值(CBF正常)。结果:20例大面积脑梗死中5例ASL-PWI显示病灶范围较DWI大,9例两者显示范围相当,5例前者小于后者,1例未见异常灌注区;14例小面积脑梗死中6例显示低灌注区,7例未能明确显示低灌注区,1例灌注增强;除1例灌注增强病例CBF病变大于CBF正常外,其它均小于后者。结论:在1.5T磁场强度上应用ASL-PWI技术能基本反映脑梗死区血流灌注的改变,其严格的相关性及临床意义有待于进一步探索。Objective：To investigate the feasibility of arterial spin labeling（ASL）perfusion 1.5T MR imaging in assessment of cerebral infarction.Methods：34 patients of cerebral infarction with ASL-perfusion MR imaging,conventional T1 and T2-weighted imagings,diffusion weighted imaging（DWI）and furthermore,magnetic resonance angiography（MRA）were reviewed and divided into two groups,large and small areas of infarction,according to Adamas classification.Areas of infarction measured on ASL-perfusion MR imaging and DWI were compared,cerebral blood flow（CBF）values in abnormal and contralateral normal regions were compared.Results：There were 20 massive infarctions and 14 small area infarctions.Of the 20 massive infarctions,ASL-perfusion MR imaging revealed larger area of low perfusion than that of DWI in 5 cases,equal in area for 9,less extent in 5 and no abnormal perfusion in one.Of the 14 cases of small infarction,ASL-perfusion MR imaging depicted low perfusion area in 6 cases,high perfusion in one,and failed to reveal any definite abnormal perfusion in 7 cases.Cerebral blood flow（CBF）values in all abnormal regions were lower than those of the normal regions,except one case showed the reversal of high perfusion.Conclusion：Perfusion changes in cerebral infarction using ASL-perfusion 1.5T MR imaging can be basically and practically utilized for depicting cerebral blood flows,but further study is necessary for strict correlation and clinical significance.

关 键 词：磁共振成像 动脉自旋标记 灌注成像 脑梗死 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.33[医药卫生—诊断学]