谷氨酰胺强化营养对重型颅脑损伤患者内脏蛋白的影响  

The effect of in glutamine-enriched nutrition to visceral protein of patients with serious head injury

作　　者：朱子健[1] 方强[1] 胡林旺[1] 

机构地区：[1]湖南省马王堆医院神经外科,长沙市410016

出　　处：《临床合理用药杂志》2010年第14期24-25,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的采用谷氨酰胺(Gln)强化营养支持,观察其对早期重型颅脑损伤患者血清白蛋白(ALB)、转铁蛋白(TRF)、前白蛋白(PAB)的影响。方法将重型颅脑损伤患者62例随机分为试验组和对照组,各31例。所有患者入院第1天常规营养支持,试验组加Gln强化的肠外营养(PN)支持7d。对照组按传统方法进行营养支持。2组治疗前和治疗后的第7天检测ALB、TRF、PAB含量。结果 2组治疗后AlB、TRF、PAB均下降(P<0.05或P<0.01);治疗后2组ALB、TRF、PAB水平比较,差异有统计学意义(P<0.01)。结论 Gln在重型颅脑损伤中应用能改善患者营养状态,相对缓和患者的高分解状态。Objective To observe the effect of serum albumin（ALB）,serum transferrin（TRF）,pre-albumin（PAB） of the serious head injury patients that were gave glutamine（Gln）-enriched nutritional supported in early stage.Methods 62 patients with serious head injury were randomly divided into experimental group and control group,each of 31 cases.All the patients were given the conventional nutritional support,and the experimental group were supplied glutamine-enriched parenteral alimentation（PN） 7 days.The control group were gave nutrition support of traditional method.Then the lever of ALB,TRF and PAB were detected before treatment and after glutamine-enriched 7 days.Results After treatment,ALB,TRF and PAB of two groups were down（P0.05 or P0.01）;After treatment,compared with the lever of ALB,TRF and PAB of two groups,the difference were statistics（P0.01）.Conclusion Gln application in serious head injury can improve the nutritional status of patients and relax the patient′s high state of decomposition relatively.

关 键 词：谷氨酰胺 颅脑损伤 重型 血清白蛋白 血清转铁蛋白 血清前白蛋白 营养支持 

分 类 号：R651.15[医药卫生—外科学]