肇东市农村地区<20岁人群乙型肝炎病毒流行情况分析  

Analysis on HBV Epidemical Trend of People Age<20 from Rural Areas of Zhaodong

作　　者：王锋[1] 刘彦成[2] 王开利[2] 张静[2] 于楠 张勇[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室,北京100052 [2]黑龙江省疾病预防控制中心,哈尔滨150030 [3]肇东市疾病预防控制中心,黑龙江肇东151100

出　　处：《中国疫苗和免疫》2010年第3期211-213,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的通过两次调查肇东市农村地区<20岁人群乙型肝炎(乙肝)病毒(Hepatitis B Virus,HBV)感染情况,分析该地区1886～2005年乙肝病毒表面抗原(HBV Surface Antigen,HBsAg)、抗乙肝病毒表面抗原抗体(Antibody to HBsAg,Anti-HBs)、抗乙肝病毒核心抗原抗体(Antibody to HBV Core Antigen,Anti-HBc)感染标志变化,了解该地区乙肝疫苗(Hepatitis B Vaccine,HepB)的免疫预防效果。方法分别于1986、2005年,对该地区进行横断面调查并采集血标本,用固相放射免疫法检测血清中HBsAg、Anti-HBs、Anti-HBc,分析这三项感染指标的流行情况。结果该地区<20岁人群HBsAg平均阳性率,由1986年的8.5%下降到2005年的4.4%(χ2=10.88,P<0.01),Anti-HBs平均阳性率由18.3%上升到43.1%(χ2=130.47,P<0.01),Anti-HBc平均阳性率由39.9%下降到15.1%(χ2=122.18,P<0.01)。结论肇东市农村地区<20岁人群HBV感染率本底高,1986年使用HepB后,HBV感染率下降明显,但仍高于全国平均水平,提示该地区HepB接种迫切需要加强和改进。Objective By two times investigation to the HBV infection of people age20 in rural areas in Zhaodong city,to understand the effects of HepB immunigation through analysing the changes of HBsAg、anti-HBs and anti-HBc infectious markers during 1986～2005.MethodsCross-sectional study was conducted and the surum samples were collected in 1986 and 2005 respectively.HBsAg、anti-HBs and anti-HBc of the sera with SPRIA were tested.ResultsHBsAg average positive rate of the people age20 decreased from 8.5% in 1986 to 4.4% in 2005（c2=10.88,P0.01）.The anti-HBs average positive rate increased to 43.1%in 2005 from 18.3% in 1986（c2=130.47,P0.01）.The anti-HBc average positive rate decreased from 39.9% to 15.1%（c2=122.18,P0.01）.ConclusionThe HBV infectious background of the rural population in Zhaodong city is high and the HBV infection rate decreased obviously after HepB inoculation since 1986,but it is still higher than the state average rate.It indicated that the HBV prevention in this district need to be enforced and improved.

关 键 词：乙型肝炎病毒感染 横断面调查 乙型肝炎疫苗 免疫效果 

分 类 号：R373.2[医药卫生—病原生物学] R186[医药卫生—基础医学]