甘肃省不同人群甲型H_1N_1流行性感冒病毒抗体检测结果分析  

Analysis of Influenza Type A(H_1N_1) Antibody Levels in Different Population in Gansu Province

作　　者：于德山[1] 李红育[1] 高续明[1] 刘建地[1] 刘新凤[1] 李保娣[1] 蓝弘[1] 孟蕾[1] 

机构地区：[1]甘肃省疾病预防控制中心,兰州730000

出　　处：《中国疫苗和免疫》2010年第3期219-221,260,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解甘肃省2009年不同时期一般人群、甲型H1N1流行性感冒(甲流)康复者、疫苗接种者三类人群的甲流抗体水平。方法采用血凝抑制(Hemagglutination Inhibition,HI)试验检测HI抗体,≥1:40为阳性。结果 2009年8月底、11月底,甘肃省城市人群甲流抗体阳性率分别为3.64%(11/302)和10.45%(44/421)。2009年接种甲流疫苗后30d抗体阳性率46.13%(131/284),几何平均滴度(Geometric Mean Titer,GMT)为1:21.31。实验室确诊病例发病10～15d血清HI抗体阳性率为87.04%(47/54),15d后抗体阳性率为96.40%(134/139);GMT为1:139.4。结论甘肃省甲流首先在学生中形成爆发,目前已经扩散到不同年龄人群,人群甲流抗体水平仍很低,疫苗接种率低(6.65%),人群普遍对甲流缺乏免疫力,甲流将继续在人群中流行。加强甲流疫苗接种、做好重症病例的救治,依然是当前预防控制的重点。Objective To investigate influenza type A（H1N1） antibody levels in 3 different population which included common people,people recovered from be infected with influenza A（H1N1） and people vaccinated influenza type A（H1N1） vaccine in Gansu province in 2009.MethodsHemagglutination Inhibition（HI） test,HI test is positive when HI-titer≥1：40.ResultsThe influenza type A（H1N1） antibody-positive rate of urban population were 3.64%（11/302） and 10.45%（44/421） in Gansu province in August and later November respectively.The antibody-positive rate of people vaccinated after 30 days was 46.13%（131/284）,GMT was 1：21.31.10-15 days after infected by influenza type A（H1N1）,HI antibody-positive rate was 87.04%,it rose to 96.40% after 15 days vaccination,and GMT was 1：139.4.ConclusionIn Gansu,Influenza A H1N1 outbroke firstly among students.Currently,all age groups were reported being infected with the influenza typeA H1N1 virus.Only 6.65% of residents were given vaccination,antibody level of influenza type A H1N1 in people was low.Influenza type A（H1N1） virus will continue to spread in Gansu.Strengthening vaccination and improving treatment to serious cases were recommended strategies for influenza type A H1N1 control and prevention.

关 键 词：甲型H1N1流行性感冒 血凝抑制抗体 检测 

分 类 号：R511.7[医药卫生—内科学] R186[医药卫生—临床医学]